Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients

Autor: F. Perrin, Pierre Pottier, Maxime Samson, Thomas Le Gallou, Pascal Roblot, Anabele Dos Santos, Mohamed Hamidou, Alexandra Espitia-Thibault, Jérôme Connault, Olivier Espitia, Christian Lavigne, Hervé Maisonneuve, Jean M. Brisseau, Jean Michel Serfaty, Patrick Jego, Julie Graveleau, Philippe Moreau, Claire de Moreuil, Georges Fau, François Maillot, Cédric Landron, Cécile Durant, Agathe Masseau, Elisabeth Diot, Cristina Belizna, M. Artifoni, Julie Magnant, Antoine Néel, Christian Agard
Přispěvatelé: Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital du Bocage, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de médecine interne et centre de référence des maladies rares [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département de Radiologie [CHU de Rennes], Université de Rennes (UR), Service de Médecine Interne, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Internal Medicine B Unit, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes], CHU Pontchaillou [Rennes], GIRC Thrombose, Service de médecine interne [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), CH Vannes, Centre hospitalier de Saint-Nazaire, CH de Lorient, Service d'hématologie, Centre hospitalier La Roche-Sur-Yon, Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier universitaire de Nantes ( CHU Nantes ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ), Centre hospitalier universitaire de Poitiers ( CHU Poitiers ), CHU Angers, CHRU Tours, Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Nutrition, croissance et cancer (U 1069) ( N2C ), Université de Tours-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de médecine interne, Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Sud, Université de Nantes ( UN ) -Hôtel-Dieu-Centre hospitalier universitaire de Nantes ( CHU Nantes ), unité de recherche de l'institut du thorax UMR1087 UMR6291 ( ITX ), Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Brenner, Nelly, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
medicine.medical_specialty
idiopathic aortitis
Immunology
030204 cardiovascular system & hematology
03 medical and health sciences
Aortic aneurysm
0302 clinical medicine
Aneurysm
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
medicine
Humans
Immunology and Allergy
In patient
cardiovascular diseases
Aortitis
Aged
Retrospective Studies
030203 arthritis & rheumatology
business.industry
giant cell arteritis
[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie
[ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Prognosis
medicine.disease
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
3. Good health
Surgery
Aortic wall
Dissection
Giant cell arteritis
Multicenter study
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
isolated aortitis
cardiovascular system
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
France
business
aortic aneurysm
Zdroj: Autoimmunity Reviews
Autoimmunity Reviews, 2016, 15 (6), pp.571-576. ⟨10.1016/j.autrev.2016.02.016⟩
Autoimmunity Reviews, Elsevier, 2016, 15 (6), pp.571-576. ⟨10.1016/j.autrev.2016.02.016⟩
Autoimmunity Reviews, Elsevier, 2016, 15 (6), pp.571-576. 〈10.1016/j.autrev.2016.02.016〉
ISSN: 1568-9972
DOI: 10.1016/j.autrev.2016.02.016⟩
Popis: International audience; Objectives: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis.Methods: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening > 2 mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared.Results: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70y, p = 0.003) and comprised more past/current smokers (43 vs 15%, p = 0.0007). Aortic aneurisms were more frequent (38% vs 20%, p = 0.03) and aortic wall thickening was more pronounced in IA. During follow-up (median = 34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p = 0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p = 0.02). Mean age, sex-ratio, inflammatory parameters and free of aortic aneurism-survival were equivalent in patients with IA ≥ 60y when compared to patients with GCA-related aortitis.Conclusions: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients < 60y. Most patients with IA ≥ 60y share many features with GCA-related aortitis.
Databáze: OpenAIRE
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