Modulation of lipid-induced ER stress by fatty acid shape

Autor: Gilles Frapper, Ludovic Pineau, Sébastien Dupont, Adrià Gil, Thierry Ferreira, Laurent Beney, Ellen Claire Rowland Snyder, Julie Deguil
Přispěvatelé: Institut de physiologie et biologie cellulaires (IPBC), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Pharmacologie - EA 1046, Université de Lille, Department of Biochemistry, University of Geneva [Switzerland], Génie des Procédés Microbiologiques et Alimentaires (GPMA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Laboratoire de catalyse en chimie organique (LACCO), Université de Poitiers-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), Institut de physiologie et biologie cellulaires ( IPBC ), Université de Poitiers-Centre National de la Recherche Scientifique ( CNRS ), Génie des Procédés Microbiologiques et Alimentaires ( GPMA ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Laboratoire de Catalyse en Chimie Organique, Université de Poitiers
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Models
Molecular
Lipid Bilayers
[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
Endoplasmic Reticulum
Biochemistry
03 medical and health sciences
0302 clinical medicine
[ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biomolecules [q-bio.BM]
Structural Biology
Stress
Physiological
Genetics
Humans
adipocyte protein 2
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
Molecular Biology
Unsaturated fatty acid
Cells
Cultured
Phospholipids
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
biology
Endoplasmic reticulum
Fatty Acids
[ SDV.BC.BC ] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
food and beverages
Fatty acid
Cell Biology
Lipids
Cell biology
chemistry
Lipotoxicity
Free fatty acid receptor
Unfolded protein response
biology.protein
Fatty Acids
Unsaturated
030217 neurology & neurosurgery
Polyunsaturated fatty acid
Zdroj: Traffic
Traffic, Wiley, 2011, 12 (3), pp.349-62. ⟨10.1111/j.1600-0854.2010.01150.x⟩
Traffic, 2011, 12 (3), pp.349-62. ⟨10.1111/j.1600-0854.2010.01150.x⟩
Traffic, Wiley, 2011, 12 (3), pp.349-62. 〈10.1111/j.1600-0854.2010.01150.x〉
ISSN: 1398-9219
1600-0854
DOI: 10.1111/j.1600-0854.2010.01150.x⟩
Popis: IF : 5,709; International audience; Exposure of pancreatic β cells to long-chain saturated fatty acids (SFA) induces a so-called endoplasmic reticulum (ER) stress that can ultimately lead to cell death. This process is believed to participate in insulin deficiency associated with type 2 diabetes, via a decrease in β-cell mass. By contrast, some unsaturated fatty acid species appear less toxic to the cells and can even alleviate SFA-induced ER stress. In the present study, we took advantage of a simple yeast-based model, which brings together most of the trademarks of lipotoxicity in human cells, to screen fatty acids of various structures for their capacity to counter ER stress. Here we demonstrate that the tendency of a free fatty acid (FFA) to reduce SFA toxicity depends on a complex conjunction of parameters, including chain length, level of unsaturation, position of the double bonds and nature of the isomers (cis or trans). Interestingly, potent FFA act as building blocks for phospholipid synthesis and help to restore an optimal membrane organization, compatible with ER function and normal protein trafficking.
Databáze: OpenAIRE
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