Increased prevalence of val(66)met BDNF genotype among subjects with cervical dystonia
| Autor: | Neal Hermanowicz, Shawn Nguyen, Maureen Haske-palomino, Ajay Sampat, Steven C. Cramer, Vincent Procaccio |
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| Přispěvatelé: | Biologie Neurovasculaire Intégrée (BNVI), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Apolipoprotein E
Male Plasticity Genotype [SDV]Life Sciences [q-bio] Physiology Disease Article Pathogenesis 03 medical and health sciences 0302 clinical medicine Genetic Neuroplasticity Genetics medicine Psychology Humans Cervical dystonia Parkinson Disease/genetics Polymorphism Torticollis 030304 developmental biology Aged Brain-derived neurotrophic factor Dystonia 0303 health sciences Polymorphism Genetic Brain-Derived Neurotrophic Factor General Neuroscience Brain-Derived Neurotrophic Factor/genetics Neurosciences Parkinson Disease Middle Aged Torticollis/genetics medicine.disease nervous system diseases Cognitive Sciences Female Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Letters Neuroscience Letters, 2010, 468 (1), pp.42-5. ⟨10.1016/j.neulet.2009.10.059⟩ Cramer, Steven C; Sampat, Ajay; Haske-Palomino, Maureen; Nguyen, Shawn; Procaccio, Vincent; & Hermanowicz, Neal. (2010). Increased prevalence of val(66)met BDNF genotype among subjects with cervical dystonia.. Neuroscience letters, 468(1), 42-45. doi: 10.1016/j.neulet.2009.10.059. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1qf9288f |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/j.neulet.2009.10.059⟩ |
| Popis: | International audience; Abnormalities of cortical representational maps and their plasticity have been described in dystonia. A common polymorphism for BDNF has been associated with abnormal cortical plasticity, and thus might contribute to pathogenesis of dystonia in some subjects. As a first step towards this suggestion, the current study examined the prevalence of this polymorphism. BDNF genotype was examined in 34 subjects with cervical dystonia, 54 age-matched healthy controls, and 53 subjects with a different movement disorder, Parkinson's disease. ApoE genotype, known to influence neurological outcome in some conditions, was also examined as a control. In subjects with cervical dystonia, the val(66)met polymorphism was approximately twice as prevalent when compared to either control group. This was not true of ApoE genotype, which was similarly distributed across subject groups. The current findings suggest that the BDNF val(66)met polymorphism might play a role in the pathogenesis of cervical dystonia in some subjects. |
| Databáze: | OpenAIRE |
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