Alcohol Cue–Induced Ventral Striatum Activity Predicts Subsequent Alcohol Self‐Administration

Autor: Lindsay R. Meredith, Elizabeth M. Burnette, Suzanna Donato, Alexandra Venegas, Lara A. Ray, ReJoyce Green, Aaron C. Lim, Erica N. Grodin
Rok vydání: 2020
Předmět:
Adult
Male
Taste
Genotype
Receptors
Opioid
mu
030508 substance abuse
Medicine (miscellaneous)
Self Administration
Alcohol
Toxicology
Placebo
Gyrus Cinguli
Aldehyde Dehydrogenase 1 Family
Article
Naltrexone
Random Allocation
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Thalamus
Neuroimaging
Humans
Medicine
Proportional Hazards Models
Neural correlates of consciousness
Ethanol
business.industry
Aldehyde Dehydrogenase
Mitochondrial
Functional Neuroimaging
Ventral striatum
Central Nervous System Depressants
Magnetic Resonance Imaging
Psychiatry and Mental health
medicine.anatomical_structure
chemistry
Ventral Striatum
Multilevel Analysis
Female
Cues
0305 other medical science
Self-administration
business
Alcohol-Related Disorders
030217 neurology & neurosurgery
Alcohol Deterrents
Clinical psychology
medicine.drug
Zdroj: Alcohol Clin Exp Res
ISSN: 1530-0277
0145-6008
DOI: 10.1111/acer.14342
Popis: Author(s): Lim, Aaron C; Green, ReJoyce; Grodin, Erica N; Venegas, Alexandra; Meredith, Lindsay R; Donato, Suzanna; Burnette, Elizabeth; Ray, Lara A | Abstract: BackgroundHuman laboratory paradigms are a pillar in medication development for alcohol use disorders (AUD). Neuroimaging paradigms, in which individuals are exposed to cues that elicit neural correlates of alcohol craving (e.g., mesocorticolimbic activation), are increasingly utilized to test the effects of AUD medications. Elucidation of the translational effects of these neuroimaging paradigms on human laboratory paradigms, such as self-administration, is warranted. The current study is a secondary analysis examining whether alcohol cue-induced activation in the ventral striatum is predictive of subsequent alcohol self-administration in the laboratory.MethodsNon-treatment-seeking heavy drinkers of East Asian descent (nn=n41) completed a randomized, placebo-controlled, double-blind, crossover experiment on the effects of naltrexone on neuroimaging and human laboratory paradigms. Participants completed 5ndays of study medication (or placebo); on day 4, they completed a neuroimaging alcohol taste cue-reactivity task. On the following day (day 5), participants completed a 60-minute alcohol self-administration paradigm.ResultsMultilevel Cox regressions indicated a significant effect of taste cue-elicited ventral striatum activation on latency to first drink, Wald χ2 n=n2.88, pn=n0.05, such that those with higher ventral striatum activation exhibited shorter latencies to consume their first drink. Similarly, ventral striatum activation was positively associated with total number of drinks consumed, F(1, 38)n=n5.90, p = 0.02. These effects were significant after controlling for alcohol use severity, OPRM1 genotype, and medication. Other potential regions of interest (anterior cingulate, thalamus) were not predictive of self-administration outcomes.ConclusionsNeuroimaging alcohol taste cue paradigms may be predictive of laboratory paradigms such as self-administration. Elucidation of the relationships among different paradigms will inform how these paradigms may be used synergistically in experimental medicine and medication development.
Databáze: OpenAIRE
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