The impact of neuropsychiatric disease on fetal growth: a case-control study
| Autor: | Anke Rissmann, Lara Südekum, Anke Redlich, Sven Seeger, Serban-Dan Costa, Gerhard Jorch, Siegfried Kropf, Ligang Zhou, Anja Radusch |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Cephalometry Substance-Related Disorders Birth weight Intrauterine growth restriction Fetal Development 03 medical and health sciences Epilepsy 0302 clinical medicine Pregnancy Risk Factors medicine Birth Weight Humans Risk factor Depression (differential diagnoses) Retrospective Studies 030219 obstetrics & reproductive medicine Fetal Growth Retardation Obstetrics business.industry Depression Mental Disorders Case-control study Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Prenatal Care General Medicine medicine.disease Substance abuse Pregnancy Complications 030220 oncology & carcinogenesis Case-Control Studies Infant Small for Gestational Age Female business |
| Zdroj: | Archives of gynecology and obstetrics. 300(6) |
| ISSN: | 1432-0711 |
| Popis: | To determine the impact of depression, epilepsy and drug abuse during pregnancy on delivery and fetal outcome. Due to the worldwide increasing prevalence of neurological and psychiatric diseases and drug abuse, the number of affected pregnant women is increasing. A large-scale retrospective case–control analysis of pregnancies affected by depression, epilepsy or drug abuse with and without medication was conducted in two German perinatal centres between 2013 and 2017. The case group consisted of 706 pregnant women who had a diagnosis of depression, epilepsy or drug abuse vs. 12,574 pregnant women without neuropsychiatric diagnosis (control group). The analysis included the rate of intrauterine growth restriction, birth weight and length, neonatal head circumference. Significant differences in the subgroups were found in the parameters intrauterine growth restriction, birth weight, length and head circumference. Women with epilepsy were affected less often than women with depression and substance abuse. Major differences were found in the group of women with substance abuse. Negative associations were found within the non-pharmacologically managed disease group itself compared to women exposed to medication. The present results demonstrated a negative association between maternal neurological or psychiatric disease and pregnancy outcome in the examined parameters. However, the non-pharmacologically treated maternal disease was identified as a risk factor itself. |
| Databáze: | OpenAIRE |
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