Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians
| Autor: | Shinji Yashiki, Kazuo Tajima, Tomoyuki Miura, Vladimir Zaninovic, Abraham Blank, Hiroshi Ohnishi, William J. Harrington, Masanori Hayami, M. Kuwayama, John J. Byrnes, Toshinobu Fujiyoshi, Chihaya Fujiyama, Luis Cartier, Hiroki Miyashita, Shunro Sonoda, Michelle Blank |
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| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
viruses Molecular Sequence Data Population Ethnic group Biology immune system diseases HLA-DQ Antigens hemic and lymphatic diseases parasitic diseases HLA-DQ beta-Chains Humans Allele education HLA-DRB1 Genotyping Alleles Genetics Human T-lymphotropic virus 1 education.field_of_study Base Sequence Indians South American Human T-lymphotropic virus 2 Haplotype virus diseases HLA-DR Antigens Haplotypes Oncology Virus type South american Carrier State HLA-DRB1 Chains |
| Zdroj: | International Journal of Cancer. 63:510-515 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910630409 |
| Popis: | To investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-II) carriers among South American native Indians, we analyzed HLA DRB1*-DQB1* haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-I-carrying Andes natives had one of the 5 HLA haplotypes: DRB1*-DQB1* 0403-0302, 0802-0402, 0901-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRB1*-DQB1* 1402-0301, 1602-0301 and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These results suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections. |
| Databáze: | OpenAIRE |
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