The association between the adapted dietary inflammatory index and colorectal cancer recurrence and all-cause mortality

Autor: Ernst Jan Spillenaar Bilgen, Johannes H. W. de Wilt, Evertine Wesselink, Ellen Kampman, Fränzel J.B. van Duijnhoven, Ewout A. Kouwenhoven, Anne J.M.R. Geijsen, Flip M. Kruyt, Renzo P. Veenstra, Moniek van Zutphen, Laura E. Staritsky, Dieuwertje E. Kok
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Oncology
Male
medicine.medical_specialty
Nutrition and Disease
Colorectal cancer
Inflammatory markers
030209 endocrinology & metabolism
Inflammation
Critical Care and Intensive Care Medicine
03 medical and health sciences
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
0302 clinical medicine
All institutes and research themes of the Radboud University Medical Center
Interquartile range
Recurrence
Internal medicine
Voeding en Ziekte
medicine
Humans
Mortality
Inflammatory potential of the diet
Prospective cohort study
Aged
VLAG
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
Middle Aged
medicine.disease
All-cause mortality
Cancer registry
Diet
Clinical trial
Interleukin 10
C-Reactive Protein
Human and Animal Physiology
Fysiologie van Mens en Dier
Cytokines
Observational study
Female
medicine.symptom
Neoplasm Recurrence
Local
business
Colorectal Neoplasms
Zdroj: Clinical Nutrition, 40(6), 4436-4443
Clinical Nutrition 40 (2021) 6
Clinical Nutrition, 40, 6, pp. 4436-4443
Clinical Nutrition, 40, 4436-4443
ISSN: 0261-5614
Popis: Background & aims: The inflammatory potential of the diet has been linked to colorectal cancer (CRC) development and mortality. However, it is unknown whether it is also associated with CRC recurrence. Therefore, the aim of this study was to investigate the associations between the inflammatory potential of the diet and plasma inflammation markers as well as recurrence and all-cause mortality in CRC patients. Methods: Data of the Colorectal cancer, Observational, LONgitudinal (COLON) study, a prospective cohort study, was used. Dietary intake, assessed using a semi-quantitative food frequency questionnaire, was available for 1478 patients at diagnosis and for 1334 patients six months after diagnosis. Dietary intake data were used to calculate the adapted dietary inflammatory index (ADII). Data about cancer recurrence and all-cause mortality, were assessed through linkage with the Netherlands Cancer Registry and the Municipal Personal Records Database, respectively. The association between the ADII (continuous) and inflammation markers (Interleukin (IL)6, IL8, IL10, Tumor Necrosis Factor (TNF)α, high sensitivity C-reactive protein (hsCRP) and a summary inflammatory z-score), measured with a multiplex assay using electrochemiluminiscence detection, was assessed using quantile regression analyses. Restricted cubic splines (RCS) analyses and multivariable Cox proportional hazard models were used to explore the relationship between the ADII and CRC outcomes. Results: During a median follow-up time of 3.2 years (Interquartile range (IQR) 2.0–4.1) for recurrence and 4.8 years (IQR 3.5–5.9) for all-cause mortality, 228 recurrences and 279 deaths occurred. A more pro-inflammatory diet at diagnosis as well as six months after diagnosis was associated with higher levels of TNFα, hsCRP and the summary inflammatory z-score. Results of RCS showed no relationship between the ADII and CRC outcomes at both time points. Also results of the Cox proportional hazard models showed no associations between the ADII at both time points and recurrence (HR (95%CI) 0.98 (0.94–1.04) & 0.96 (0.91–1.02) or all-cause mortality (HR (95%CI) 1.03 (0.98–1.07) & 1.00 (0.95–1.05)). Conclusion: Our study did not show an association between the ADII and recurrence and all-cause mortality in CRC patients. Further research should also take into account molecular tumor subtypes, as the effect of the inflammatory potential of the diet on cancer recurrence and mortality is more likely to be present in tumors with an inflammatory signature. Clinical Trial Registry numbers and website: The colon study: NCT03191110; clinical trials.gov.
Databáze: OpenAIRE
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