Salvianolic acid B induces browning in 3T3-L1 white adipocytes via activation of β3-AR and ERK signaling pathways
| Autor: | Jong Won Yun, Huong Giang Pham, Trang Thi Huyen Dang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Beige Browning Medicine (miscellaneous) White adipose tissue Salvia 03 medical and health sciences 0404 agricultural biotechnology Internal medicine parasitic diseases medicine Browning Lipolysis TX341-641 Gene 030109 nutrition & dietetics Nutrition and Dietetics biology Chemistry Nutrition. Foods and food supply 3T3-L1 Thermogenesis 04 agricultural and veterinary sciences biology.organism_classification Salvianolic acid B 040401 food science Endocrinology Lipogenesis Anti-obesity Food Science |
| Zdroj: | Journal of Functional Foods, Vol 81, Iss, Pp 104475-(2021) |
| ISSN: | 1756-4646 |
| Popis: | Salvianolic acid B (Sal B), a natural compound extracted from Salvia miltiorrhiza (Danshen), is well known for its anti-oxidative activity and treatment of cardiovascular diseases. However, little is known about the functional roles of Sal B in white adipocytes. Therefore, this study aimed to investigate the functions of Sal B in 3T3-L1 white adipocytes, with a focus on white fat browning effect. Exposure to Sal B significantly increased the expressions of beige-specific genes and thermogenic marker proteins. Sal B also suppressed lipogenesis and enhanced lipolysis in white adipocytes. A mechanistic study revealed that Sal B stimulates white fat browning via β3-AR and ERK signaling pathways in an independent manner. In conclusion, our findings indicate that Sal B is beneficial in the prevention and treatment of obesity, at least in part by promoting thermogenesis. |
| Databáze: | OpenAIRE |
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