Alterations in T-Cell Subset Frequency in Peripheral Blood in Obesity
| Autor: | Blair A. Jobe, Robert W. O’Rourke, Tom S. Kay, Antony C. Bakke, Brian S. Diggs, Mark H Scholz, David M. Lewinsohn |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Lymphocyte T cell Peripheral blood mononuclear cell Body Mass Index Immune system Antigen Antigens CD T-Lymphocyte Subsets Internal medicine medicine Humans Lymphocyte Count Nutrition and Dietetics biology business.industry Middle Aged Obesity Morbid medicine.anatomical_structure Endocrinology Case-Control Studies Peripheral blood lymphocyte Immunology biology.protein Female Surgery Antibody business CD8 |
| Zdroj: | Obesity Surgery. 15:1463-1468 |
| ISSN: | 1708-0428 0960-8923 |
| Popis: | Background: Obesity affects the regulation of immune and inflammatory responses. This study characterizes differences in peripheral blood lymphocyte phenotype in obese humans. Methods: Frequencies of lymphocyte subsets among peripheral blood mononuclear cells were compared between 10 obese (BMI ≥35) and 10 lean subjects, as determined by antibodies directed against cluster differentiation (CD) markers. Results: Obese patients demonstrated an increased frequency of CD3+CD4+ T-cells (mean difference 12%, P=0.004), a decreased frequency of CD3+CD8+ T-cells (mean difference 9.4%, P=0.016) and an increased frequency of CD3+CD8+CD95+ T-cells (mean difference 13.3%, P=0.032). No other differences among T-cell or monocyte subsets were noted. Conclusions: Obesity is associated with alterations in frequencies of peripheral CD4+ and CD8+ T-cells and aberrations in the expression of CD95 among CD8+ T-cells. These data suggest both CD4+ and CD8+ T-cell compartments, as well as the regulation of CD95 expression on CD8+ T-cells, as targets for further study into obesity's effects on the immune system. |
| Databáze: | OpenAIRE |
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