Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes
| Autor: | Christian Brander, David T. Scadden, Todd J. Suscovich, Sheila C. Dollard, Tania M. Welzel, Daniel Kaufmann, Kenneth M. Kaye, Elizabeth E. Brown, Jeffrey N. Martin, Fred Wang, John V. Chisholm, Leah M. Henry, Murli Narayan, Florian Bihl, Tauheed Zaman |
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| Rok vydání: | 2007 |
| Předmět: |
Herpesvirus 4
Human Cellular immunity T-Lymphocytes viruses T cell Immunology medicine.disease_cause Microbiology Virus Herpesviridae Immunophenotyping Epitopes Viral Proteins Virology medicine Humans Gammaherpesvirinae Kaposi's sarcoma-associated herpesvirus Antigens Viral Immunity Cellular biology virus diseases biochemical phenomena metabolism and nutrition biology.organism_classification Epstein–Barr virus medicine.anatomical_structure Lytic cycle Insect Science Herpesvirus 8 Human Pathogenesis and Immunity Immunologic Memory |
| Zdroj: | Journal of Virology. 81:4904-4908 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.02509-06 |
| Popis: | The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses. |
| Databáze: | OpenAIRE |
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