HLA-DP variation as additional risk factor in IDDM
| Autor: | Maija R.J. Kohonen-Corish, Susan W. Serjeantson, Simon Easteal, Paul Zev Zimmet |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Linkage disequilibrium
HLA-DP Antigens endocrine system diseases Endocrinology Diabetes and Metabolism Genetic Variation HLA-DP HLA-DR Antigens Biology medicine.disease Diabetes Mellitus Type 1 Interactive effects Antigen Haplotypes immune system diseases Risk Factors Diabetes mellitus Insulin dependent diabetes HLA-DQ Antigens Healthy control Immunology Internal Medicine medicine Humans Polymorphism Restriction Fragment Length |
| Zdroj: | Diabetes. 39(7) |
| ISSN: | 0012-1797 |
| Popis: | A significant increase in the frequency of DPw3/6 aleeles defined by restriction-fragment–length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P < 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4. |
| Databáze: | OpenAIRE |
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