Gray matter volume abnormalities in type 2 diabetes mellitus with and without mild cognitive impairment
| Autor: | Qiao-Ying Yuan, Luqing Wei, Yanwei Zhang, Jiuquan Zhang, Xiao Zhang, Ran Tao, Jinguo Cui, Xuntao Yin, Chen Liu, Jian Wang, Ping Wei |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system diseases Middle temporal gyrus computer.software_genre behavioral disciplines and activities Temporal lobe Atrophy Voxel Internal medicine mental disorders Image Processing Computer-Assisted medicine Humans Cognitive Dysfunction Aged Brain Mapping medicine.diagnostic_test General Neuroscience Brain nutritional and metabolic diseases Magnetic resonance imaging Voxel-based morphometry Middle Aged Medial frontal gyrus medicine.disease Magnetic Resonance Imaging nervous system diseases medicine.anatomical_structure Diabetes Mellitus Type 2 Cardiology Female Brain Gray Matter Psychology Neuroscience computer |
| Zdroj: | Neuroscience Letters. 562:1-6 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2014.01.006 |
| Popis: | This study sought to evaluate the potential brain gray matter (GM) volume changes that occur with the transition from normal cognition to mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus (T2DM) using voxel-based morphometry (VBM). VBM analyses of brain GM based on magnetic resonance imaging (MRI) data were performed on 28 T2DM patients with MCI, 25 T2DM patients without MCI, 28 MCI patients and 29 healthy controls (HC). Compared with the HC, the T2DM patients both with and without MCI showed significantly decreased total GM volume. Furthermore, the VBM results indicated that the T2DM patients without MCI exhibited extensively decreased GM volume compared with the HC in certain brain regions, including the superior and middle temporal gyrus (MTG), the superior and medial frontal gyrus and the middle occipital gyrus. In addition to more extensive GM atrophy in the aforementioned brain regions, the medial temporal lobe also exhibited GM loss in the T2DM patients with MCI. Furthermore, relative to the patients without MCI, only the left MTG exhibited a lower GM volume in the T2DM patients with MCI, which was positively correlated with the total MoCA score (r=0.699, P0.01). Finally, relative to MCI, the left MTG atrophy was also found in the T2DM patients with MCI. Our findings suggest that MTG atrophy was associated with an increased risk for MCI in T2DM patients. The brain structural changes in many brain regions may underlie the transition from normal cognition to MCI in T2DM patients. |
| Databáze: | OpenAIRE |
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