In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants
| Autor: | Arunachalam Muthaiyan, V M Ramesh, Daisy Savarirajan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Saponin
Antifungal drug General Physics and Astronomy Microsporum nanum Microsporum gypseum General Biochemistry Genetics and Molecular Biology Cassia Dermatophytic fungi Dermatophytosis medicine Asparagus racemosus General Materials Science Trichophyton Antifungal activity Medicinal plants QD1-999 General Environmental Science QD71-142 biology Traditional medicine food and beverages General Chemistry Plant extracts Cassia occidentalis biology.organism_classification medicine.drug_formulation_ingredient Chemistry Cladosporium herbarum Anthraquinone Analytical chemistry Research Article |
| Zdroj: | Journal of Analytical Science and Technology, Vol 12, Iss 1, Pp 1-13 (2021) Journal of Analytical Science and Technology |
| ISSN: | 2093-3371 |
| Popis: | Fungal infections are among the most difficult diseases to manage in humans. Eukaryotic fungal pathogens share many similarities with their host cells, which impairs the development of antifungal compounds. Therefore, it is desirable to harness the pharmaceutical potential of medicinal plants for antifungal drug discovery. In this study, the antifungal activity of sixteen plant extracts was investigated against selected dermatophytic fungi. Of the sixteen plants, the cladode (leaf) ofAsparagus racemosus,and seed extract ofCassia occidentalisshowed antifungal activity againstMicrosporum gypseum,Microsporum nanum,Trichophyton mentagrophytesandTrichophyton terrestre. The plant antifungal compounds were located by direct bioassay againstCladosporium herbarum.IR and NMR spectrometry analyses of these compounds identified the presence of saponin (inA. racemosus) and hydroxy anthraquinone (inC. occidentalis) in these antifungal compounds. The antidermatophytic activity of plant anthraquinone and saponins with reports of little or no hemolytic activity, makes these compounds ideal for alternative antifungal therapy and warrants further in-depth investigation in vivo. |
| Databáze: | OpenAIRE |
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