Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils
| Autor: | Fabio Tentor, Pasquale Sacco, Renzo Menegazzi, Massimiliano Borgogna, Sergio Paoletti, Eleonora Marsich, Kåre Andre Kristiansen, Kjell Morten Vårum, Eva Decleva |
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| Přispěvatelé: | Sacco, Pasquale, Decleva, Eva, Tentor, Fabio, Menegazzi, Renzo, Borgogna, Massimiliano, Paoletti, Sergio, Kristiansen, Kåre Andre, Vårum, Kjell Morten, Marsich, Eleonora |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
human neutrophils Polymers and Plastics Neutrophils Sus scrofa 02 engineering and technology Neutrophil Activation chemistry.chemical_compound Superoxides Hyaluronic acid Materials Chemistry Hyaluronic Acid Internalization butyrate chitosan/hyaluronan nanoparticles inflammation reactive oxygen species media_common chemistry.chemical_classification chitosan/hyaluronan nanoparticle Superoxide 021001 nanoscience & nanotechnology Controlled release Endocytosis Cell biology Butyrates Biochemistry Tumor necrosis factor alpha medicine.symptom 0210 nano-technology Biotechnology media_common.quotation_subject Bioengineering Inflammation human neutrophil Butyrate Biomaterials 03 medical and health sciences Cell Adhesion medicine Animals Humans Chitosan Reactive oxygen species Tumor Necrosis Factor-alpha Mucins Hydrogen Peroxide Fibronectins Drug Liberation 030104 developmental biology chemistry Nanoparticles |
| Zdroj: | Sacco, P, Decleva, E, Tentor, F, Menegazzi, R, Borgogna, M, Paoletti, S, Kristiansen, K A, Vårum, K M & Marsich, E 2017, ' Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils ', Macromolecular Bioscience, vol. 17, no. 11, 1700214 . https://doi.org/10.1002/mabi.201700214 |
| Popis: | Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutrophil ROS release in a dose and time-dependent fashion. Given the short half-life of butyrate, chitosan/hyaluronan nanoparticles are next designed and developed as controlled release carriers able to provide cells with a long-lasting supply of this SCFA. Notably, while the inhibition of neutrophil ROS production by free butyrate declines over time, that of butyrate-loaded chitosan/hyaluronan nanoparticles (B-NPs) is sustained. Additional valuable features of these nanoparticles are inherent ROS scavenger activity, resistance to cell internalization, and mucoadhesiveness. B-NPs appear as promising tools to limit ROS-dependent tissue injury during inflammation. Particularly, by virtue of their mucoadhesiveness, B-NPs administered by enema can be effective in the treatment of inflammatory bowel diseases. |
| Databáze: | OpenAIRE |
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