Clinical and Imaging Characteristics Associated with Color Vision Impairment in Lewy Body Disease
| Autor: | Robert H Unger, Mitra Khosravi, James B. Leverenz, Patrick M Flanigan, Babak Tousi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Lewy Body Disease Male medicine.medical_specialty Color vision Color Vision Defects Disease Neuropsychological Tests Logistic regression Temporal lobe 03 medical and health sciences 0302 clinical medicine Cognition Internal medicine mental disorders medicine Humans Cognitive decline Aged Retrospective Studies Aged 80 and over Dopamine Plasma Membrane Transport Proteins Color Vision Dementia with Lewy bodies business.industry General Neuroscience Medical record Montreal Cognitive Assessment Brain General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging nervous system diseases Psychiatry and Mental health Clinical Psychology 030104 developmental biology Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's disease : JAD. 72(4) |
| ISSN: | 1875-8908 |
| Popis: | Background Color vision impairment (CVI) has been reported in dementia with Lewy bodies (DLB) and prodromal Lewy body disease (pro-LBD). Objective In order to better characterize the diagnostic value of CVI testing, we compared the prevalence of CVI in patients with with Lewy body disease compared to Alzheimer's disease (AD), and we examined clinical and imaging characteristics associated with CVI in patients with DLB and suspected pro-LBD. Methods We retrospectively reviewed medical records, dopamine transporter (DaT-SPECT) imaging, and volumetric MRI from patients with AD, DLB, and suspected pro-LBD who underwent an online Farnsworth D-15 color vision test. Results 111 patients (62 DLB, 25 pro-LBD, and 24 AD) were included with a median age of 75 years. Newly diagnosed CVI was present in 67% of patients with DLB, 44% of patients with pro-LBD, and 18% of patients with AD. In patients with DLB, CVI was associated with lower Montreal Cognitive Assessment (MoCA) scores and lower sub-scores in visuospatial/executive function, naming, and language. In a multivariable logistic regression model, a diagnosis of DLB or pro-LBD compared to AD, and a lower composite MoCA score in visuospatial/executive function, naming, and language were associated with CVI controlling for age and gender. Among 17 DLB patients who underwent volumetric MRI, patients with CVI (n = 9) demonstrated lower normative volumetric percentiles in the right transverse superior temporal lobe. Conclusion We provide further evidence that CVI can help differentiate DLB from AD, and we suggest that CVI may be an indicator of cognitive decline and disease progression in DLB. |
| Databáze: | OpenAIRE |
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