A preliminary study of cortical morphology in schizophrenia patients with a history of violence
| Autor: | Cato Røsæg, Arvid Jensen, Ingrid Melle, Guttorm Breivik Storvestre, Petter Andreas Ringen, Ole A. Andreassen, Andres Server, Natalia Tesli, Knut-Erik Hymer, Unn K. Haukvik, Lars Magnus Valnes, Morten Jacobsen, Stener Nerland, Ingrid Agartz |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Psychosis Sensory processing medicine.medical_treatment Neuroscience (miscellaneous) Pilot Projects Violence 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Gyrification Cerebral Cortex Aggression business.industry Perspective (graphical) Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Visual cortex medicine.anatomical_structure Schizophrenia Female Schizophrenic Psychology Orbitofrontal cortex medicine.symptom business Neuroscience 030217 neurology & neurosurgery Follow-Up Studies |
| ISSN: | 0925-4927 |
| Popis: | Clinical studies of patients with schizophrenia and a history of violence are challenging both from an ethical and practical perspective, and the neurobiological underpinnings remain largely unknown. We here present a comprehensive account of the brain cortical characteristics associated with violence in schizophrenia. We obtained 3T MRI scans and thorough clinical characterization of schizophrenia patients with a history of violence (murder, attempted murder, criminal assault, SCZ-V, n = 11), schizophrenia patients with no history of violence (SCZ-NV, n = 17), and healthy controls (HC, n = 19). Cortical thickness, area, and folding were analyzed vertex-wise across the cortical mantle (FreeSurfer). SCZ-V had significantly increased cortical folding in the visual and orbitofrontal cortex, and reduced cortical thickness within the precentral-, parietal-, temporal-, and fusiform cortex compared to SCZ-NV, as well as widespread regional thinning and increased folding compared to HC. There were no group differences in cortical area. A major limitation is the small subject sample. If replicated, the results from this pilot study suggest cortical abnormalities in areas involved in sensory processing, emotion recognition, and reward to be of importance to the neurobiology of violence in schizophrenia. |
| Databáze: | OpenAIRE |
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