Prevention of allergic sensitization to beta-lactoglobulin with conjugates made of beta-lactoglobulin coupled to isologous immunoglobulin G
| Autor: | Rodolphe Fritsché, Yves Borel |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Immunoglobulin A
Male Allergy Immunology Lactoglobulins Immunoglobulin E medicine.disease_cause Immunoglobulin G Allergic sensitization Rats Sprague-Dawley Allergen Isoantibodies medicine Immune Tolerance Immunology and Allergy Animals Mast Cells biology Chemistry food and beverages medicine.disease Mast cell Rats medicine.anatomical_structure Cross-Linking Reagents Injections Intravenous biology.protein Immunization Antibody Milk Hypersensitivity |
| Zdroj: | The Journal of allergy and clinical immunology. 93(4) |
| ISSN: | 0091-6749 |
| Popis: | We have shown that, under certain conditions, a single dose of a conjugate of beta-lactoglobulin linked to isologous IgG suppresses specific antibody responses (IgE, IgG, and IgA) in rats immunized with beta-lactoglobulin. This suppression is allergen specific. It also appears to be effective when animals are first immunized and then tolerized. In addition, administration of the beta-lactoglobulin-IgG tolerogen abolishes mast cell mediator release. This has been shown both in vivo and with passively sensitized mast cells in vitro. We propose that the construction of a tolerogen made of whole protein allergen linked to IgG could provide a novel specific therapy for allergic reactions. |
| Databáze: | OpenAIRE |
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