Associations among Serum Lipocalin-2 Concentration, Human Papilloma Virus, and Clinical Stage of Cervical Cancer
| Autor: | Joana Celiešiūtė, Daiva Vaitkienė, Agnė Vitkauskaitė, Aušra Burkauskienė, Saulius Paškauskas, Erika Skrodenienė, Rūta Jolanta Nadišauskienė |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty cervical cancer Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Gastroenterology Article Statistics Nonparametric 03 medical and health sciences 0302 clinical medicine Lipocalin-2 Cytology Internal medicine medicine Humans Stage (cooking) Papillomaviridae human papillomavirus Cervix Aged Aged 80 and over Cervical cancer lcsh:R5-920 Chi-Square Distribution biology business.industry Papillomavirus Infections Cancer General Medicine Middle Aged medicine.disease biology.organism_classification lipocalin 2 female genital diseases and pregnancy complications 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Vagina Female 618.146-006.6 [udc] lcsh:Medicine (General) business Uterine cervical neoplasms blood Biomarkers |
| Zdroj: | Medicina; Volume 55; Issue 6; Pages: 229 Medicina, Kaunas ; Basel : LSMU ; MDPI AG, 2019, vol. 55, no. 6, p. 1-10 Medicina Volume 55 Issue 6 Medicina, Vol 55, Iss 6, p 229 (2019) |
| ISSN: | 1648-9144 1010-660X |
| DOI: | 10.3390/medicina55060229 |
| Popis: | Background and objective: Lipocalin 2 (LCN2) has an oncogenic role in promoting tumorigenesis through enhancing tumor cell proliferation and the metastatic potential. The aim of our study was to determine whether serum LCN2 could serve as a diagnostic marker of cervical cancer (CC) and to evaluate the correlation between its serum concentration, the clinical stage of the cancer and Human Papilloma Virus HPV infections in women. Materials and methods: A total of 33 women with histologically proven cervical cancer (CC), 9 women with high- grade cervical intraepithelial neoplasia (HSIL) and 48 healthy women (NILM) were involved in the study. A concentration of LCN2 was assayed with the Magnetic LuminexR Assay multiplex kit. An HPV genotyping kit was used for the detection and differentiation of 15 high-risk (HR) HPV types in the liquid-based cytology medium (LBCM) and the tissue biopsy. Results: The majority (84.8%) of the women were infected by HPV16 in the CC group, and there was no woman with HPV16 in the control group (P < 0.01). Several types of HR HPV were found more often in the LBCM compared to in the tissue biopsy (P = 0.044). HPV16 was more frequently detected in the tissue biopsy than the LBCM (P < 0.05). The LCN2 level was higher in HPV-positive than in HPV-negative women (P = 0.029). The LCN2 concentration was significantly higher in women with stage IV than those with stage I CC (P = 0.021). Conclusions: Many HR HPV types, together with HPV16/18, can colonize the vagina and cervix, but often HPV16 alone penetrates into the tissue and causes CC. The serum LCN2 concentration was found to be associated not only with HR HPV infection, irrespective of the degree of cervical intraepithelial changes, but also with advanced clinical CC stage. LCN2 could be used to identify patients with advanced disease, who require a more aggressive treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|