Post-kala-azar Dermal Leishmaniasis with Mucosal Involvement: An Unusual Case Presentation including Successful Treatment with Miltefosine
| Autor: | Md. Abdus Salam, Dinesh Mondal, Muhammad Afsar Siddiqui, Khondaker Rifat Hasan Bhaskar, Shah Golam Nabi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Phosphorylcholine Health Toxicology and Mutagenesis Antiprotozoal Agents Leishmania donovani Leishmaniasis Cutaneous Serology Miltefosine treatment Pharmacotherapy parasitic diseases Maculopapular rash medicine Humans Post-kala-azar dermal leishmaniasis Bangladesh Miltefosine Case Study biology business.industry Mucosal involvement Mouth Mucosa Public Health Environmental and Occupational Health Leishmaniasis biology.organism_classification medicine.disease Treatment Outcome Visceral leishmaniasis Leishmaniasis Visceral medicine.symptom business Food Science medicine.drug |
| Zdroj: | Journal of Health, Population, and Nutrition |
| ISSN: | 1606-0997 |
| DOI: | 10.3329/jhpn.v31i2.16395 |
| Popis: | Post-kala-azar dermal leishmaniasis (PKDL) is a dermatologic manifestation that usually occurs after visceral leishmaniasis (VL) caused by Leishmania donovani. It is characterized by hypopigmented patches, a macular or maculopapular rash and nodular skin lesions on the body surface. Involvement of the mucosae is very rare and unusual in PKDL. We report a case of PKDL that presented with polymorphic skin lesions, along with involvement of peri-oral mucosa and tongue from an endemic area for kala-azar in Bangladesh. In the absence of a definite past history of kala-azar, a clinical suspicion for PKDL was confirmed by positive rapid serological tests against two recombinant (rK39 and rK28) leishmanial antigens, demonstration of Leishmania donovani (LD) body in the slit skin smear, and isolation of promastigotes by culture from a nodular lesion. The patient was treated with oral Miltefosine for three consecutive months and showed significant clinical improvement as demonstrated by a negative slit skin smear at two months after initiation of therapy. We report this case as an unusual presentation of mucosal involvement in PKDL and subsequent treatment success with Miltefosine. |
| Databáze: | OpenAIRE |
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