Stimulation of the Immune Response During Activation of the Dopaminergic System in Mice with Opposite Types of Behavior
| Autor: | G. V. Idova, M. A. Cheido, E. N. Zhukova, L. V. Devoino |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Dominance-Subordination
Male Agonist medicine.medical_specialty Neuroimmunomodulation medicine.drug_class Dopamine Stimulation Receptors Dopamine Mice Immune system Neurochemical Dopamine receptor D2 Internal medicine medicine Animals Receptor Analysis of Variance Behavior Animal Chemistry General Neuroscience Dopaminergic Aggression Endocrinology Dopamine Agonists Mice Inbred CBA Immunization Neuroscience medicine.drug |
| Zdroj: | Neuroscience and Behavioral Physiology. 34:417-421 |
| ISSN: | 0097-0549 |
| DOI: | 10.1023/b:neab.0000018755.99063.05 |
| Popis: | Studies reported here demonstrated that activation of the dopaminergic system induces increases in the immune response regardless of the type of behavior in mice (line CBA), i.e., in aggressive mice, submissive mice, and mice lacking experience of victory or defeat (controls). Changes in the activity of the dopaminergic system were induced with SKF-38393, a selective agonist of dopamine D1 receptors, and with p-chlorophenylalanine (PCPA), which we have previously shown to activate D2 receptors. In the aggressive form of behavior, which was characterized by strong (compared with controls) immune responses, SKF-38393 and PCPA led to further increases in the immune response. In submissive mice, activation of the dopaminergic system altered the nature of the immune response, with immunostimulation, as in aggression. It is suggested that activation of the dopaminergic system in conditions of defined psychoemotional status fixed by acquisition of opposite types of behavior, induces the formation of a new neurochemical pattern – the dopaminergic set – which led to changes in the nature and intensity of the immune response. |
| Databáze: | OpenAIRE |
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