Changes of serum thymic factor levels in Friend leukemia virus-infected mice
| Autor: | Laura Santucci, Giovanni B. Rossi, Vera del Gobbo, Enrico Garaci, Cristina Rinaldi-Garaci |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Time Factors T-Lymphocytes Spleen Azathioprine Mice Inbred Strains Friend leukemia virus Leukocyte Count Mice Internal medicine medicine Animals Immunological Surveillance Leukemia Experimental business.industry Immunity Hematology medicine.disease Serum Thymic Factor Cell mediated immunity Friend murine leukemia virus Thymus Hormones Leukemia Tumor Virus Infections medicine.anatomical_structure Endocrinology Oncology business medicine.drug |
| Zdroj: | Leukemia research. 3(2) |
| ISSN: | 0145-2126 |
| Popis: | Sera and spleen cells from DBA/2 and BALB/c mice were sampled at various time intervals after infection with Friend leukemia virus (FLV, polycythemic strain) and assayed for the presence of serum thymic factor (STF) and theta-positive cells, respectively. A pronounced and dose-dependent decrease of STF levels was observed in DBA/2 mice as early as 48 h after infection; STF levels were decreased in BALB/c mice, too, but the effect was less marked and long-lived than in DBA/2 mice. In close parallelism to the fall of STF levels in the sera, theta-positive cells were also found to be markedly decreased in the spleens of DBA/2 mice and, to a lesser extent, in BALB/c mice. Thetapositive cells were assayed by measuring the sensitivity to azathioprine of spleen rosette-forming cells. Both the fall of STF levels and the decrease of theta-positive spleen cells do not persist longer than 4 weeks and are not, therefore, related to the state of overt leukemia. Conceivably, though, these changes, that appear to be virus-related, may influence the early fate of FLV-transformed cells by lowering some thymus-dependent functions which may be relevant to the immunological surveillance. |
| Databáze: | OpenAIRE |
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