Torsade de pointes induced by N-Acetylprocainamide
| Autor: | William Kushner, James V. Talano, Arthur J. Atkinson, John J. Murphy, Antoni A. Piergies, Tsuen Ih Ruo, Dennis J. Bowsher, Akira Asada, May J. Chow |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Quinidine
NAPA Drug Class III antiarrhythmic drug business.industry media_common.quotation_subject Arrhythmias Cardiac Plasma levels Procainamide QT interval Electrocardiography Kinetics N-acetylprocainamide Acecainide Anesthesia Tachycardia Medicine Humans Female business Disopyramide Cardiology and Cardiovascular Medicine medicine.drug media_common Aged |
| Zdroj: | Journal of the American College of Cardiology. 4(3):621-624 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/s0735-1097(84)80111-4 |
| Popis: | N-Acetylprocainamide (NAPA), a class III antiarrhythmic drug, caused torsade de pointes in a 72 year old woman who had this arrhythmia on two previous occasions while being treated with quinidine and disopyramide. Initial evaluation with an intravenous infusion of NAPA indicated a favorable antiarrhythmic response. The QTC interval was prolonged, but the 2.4 ms/microgram per ml incremental QTC interval lengthening caused by NAPA was not greater than usual. During subsequent oral therapy with NAPA, torsade de pointes developed at plasma levels of this drug that appeared to be well tolerated during the initial evaluation. |
| Databáze: | OpenAIRE |
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