New entry to the enantioselective formation of substituted cyclohexenes bearing an all-carbon quaternary stereogenic center
| Autor: | Taku Hosaka, Yasuhiro Urayama, Keita Komine, Jun Ishihara, Hayato Fukuda, Susumi Hatakeyama |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
010405 organic chemistry Chemistry Cyclohexenes Organic Chemistry Cyclohexene Enantioselective synthesis chemistry.chemical_element 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Analytical Chemistry Stereocenter chemistry.chemical_compound Yield (chemistry) Drug Discovery Carbon Spectroscopy |
| Zdroj: | ChiralityREFERENCES. 32(3) |
| ISSN: | 1520-636X |
| Popis: | Enantioselective formation of cyclohexene derivatives bearing an all-carbon quaternary stereogenic center is described. The racemic cyclohexenes are readily transformed to chiral substituted cyclohexenes in good yield with excellent enantioselectivity and diastereoselectivity by a palladium-mediated deracemization. The resulting products are promising synthetic intermediates of biologically active natural products. This protocol provides us with a new entry to the concise and scalable synthesis of multifunctionalized compounds. |
| Databáze: | OpenAIRE |
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