The association of PTSD symptom severity with amygdala nuclei volumes in traumatized youths
| Autor: | Olga Therese Ousdal, Gertrud Sofie Hafstad, Kenneth Hugdahl, Annika Melinder, Anne Marita Milde, Grete Dyb, Tor Endestad, Alexander R. Craven, Erlend Hodneland |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adolescent
Cross-sectional study Amygdala Article lcsh:RC321-571 Stress Disorders Post-Traumatic Cellular and Molecular Neuroscience medicine Humans Association (psychology) lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry business.industry Norway Traumatic stress Symptom severity Mental illness medicine.disease Amygdala nuclei Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Cross-Sectional Studies nervous system business Psychiatric disorders Clinical psychology Neuroscience |
| Zdroj: | Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020) Translational Psychiatry |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-020-00974-4 |
| Popis: | The amygdala is a core component in neurobiological models of stress and stress-related pathologies, including post-traumatic stress disorder (PTSD). While numerous studies have reported increased amygdala activity following traumatic stress exposure and in PTSD, the findings regarding amygdala volume have been mixed. One reason for these mixed findings may be that the amygdala has been considered as a homogenous entity, while it in fact consists of several nuclei with unique cellular and connectivity profiles. Here, we investigated amygdala nuclei volumes of the basolateral and the centrocorticomedial complex in relation to PTSD symptom severity in 47 young survivors from the 2011 Norwegian terror attack 24–36 months post-trauma. PTSD symptoms were assessed 4–5, 14–15 and 24–36 months following the trauma. We found that increased PTSD symptom severity 24–36 months post-trauma was associated with volumetric reductions of all basolateral as well as the central and the medial nuclei. However, only the lateral nucleus was associated with longitudinal symptom development, and mediated the association between 4–5 months and 24–36 months post-trauma symptoms. The results suggest that the amygdala nuclei may be differentially associated with cross-sectional and longitudinal measures of PTSD symptom severity. As such, investigations of amygdala total volume may not provide an adequate index of the association between amygdala and stress-related mental illness. |
| Databáze: | OpenAIRE |
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