Construction and Validation of an Automated Flow Hydrogenation Instrument for Application in High-Throughput Organic Chemistry
| Autor: | Jeffrey Y. Pan, Bruce Clapham, David M Dingle, David P Blanchard, Daryl R. Sauer, Melissa J. Michmerhuizen, Thomas A. Nemcek, Wilson Noel S |
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| Rok vydání: | 2008 |
| Předmět: |
Chemistry
Organic Reproducibility of Results Equipment Design Robotics General Chemistry Catalysis Small Molecule Libraries chemistry.chemical_compound chemistry Fully automated Flow (mathematics) Drug Design Combinatorial Chemistry Techniques Organic chemistry Robot Organic synthesis Hydrogenation Throughput (business) |
| Zdroj: | Journal of Combinatorial Chemistry. 10:88-93 |
| ISSN: | 1520-4774 1520-4766 |
| Popis: | This manuscript details the construction of a fully automated flow hydrogenation apparatus for use in high-throughput organic synthesis. The instrument comprises of a Bohdan robot platform coupled with a ThalesNano H-cube hydrogenator and a series of solvent valves and pumping mechanisms. Using this instrument, we have been able to fully automate a number of key transformations that could not otherwise be conveniently undertaken in a high-throughput manner. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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