Topical trans-4-aminomethylcyclohexanecarboxylic acid prevents ultraviolet radiation-induced pigmentation
| Autor: | Masako Naganuma, Kazuhisa Maeda |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Ultraviolet Rays Plasmin Administration Topical Guinea Pigs Biophysics Prostaglandin Skin Pigmentation Melanocyte Biology Guinea pig Melanin chemistry.chemical_compound medicine Animals Radiology Nuclear Medicine and imaging Ultraviolet radiation Skin Melanins Arachidonic Acid Radiation Molecular Structure integumentary system Radiological and Ultrasound Technology Epidermis (botany) Molecular biology Antifibrinolytic Agents medicine.anatomical_structure Tranexamic Acid Biochemistry chemistry Arachidonic acid medicine.drug |
| Zdroj: | Journal of Photochemistry and Photobiology B: Biology. 47:136-141 |
| ISSN: | 1011-1344 |
| Popis: | We have studied the effect of a plasmin inhibitor, trans-4-aminomethylcyclohexanecarboxylic acid (trans-AMCHA), on skin pigmentation induced by ultraviolet (UV) exposure in Weiser-Maples guinea pigs. When guinea pigs are exposed to UV radiation (840 mJ cm-2), skin pigmentation is clearly observed from seven days after exposure and continued to increase to 29 days. Post-exposure applications of 2 and 3% solutions of trans-AMCHA to the exposed regions prevent or inhibit the pigmentation process. When the skin is removed and stained by the Fontana-Masson method, melanin content in the basal layer of UV-exposed epidermis is significantly reduced in the regions to which 2 and 3% trans-AMCHA solutions have been applied, compared with the vehicle control. As plasmin is known to contribute to the release of arachidonic acid (AA) and the production of prostaglandins (PGs), we have examined the effects of trans-AMCHA on AA-induced pigmentation in guinea pig skin. Topical application of trans-AMCHA causes a dose-dependent decrease in AA-induced pigmentation. These results suggest that trans-AMCHA reduces melanocyte tyrosinase activity by suppressing the production of PGs, UV-induced melanogens, through the suppression of the UV-induced increase in epidermal plasmin activity. |
| Databáze: | OpenAIRE |
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