Neural Antibody Testing for Autoimmune Encephalitis: A Canadian Single-Centre Experience
| Autor: | Pamela Edmond, Adrian Budhram, Ario Mirian, Vipin Bhayana, Sean McFadden, Liju Yang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Autoimmune encephalitis
Autoimmune disease Canada biology business.industry Cell Adhesion Molecules Neuronal General Medicine AMPA receptor Glutamic acid Hashimoto Disease medicine.disease Neuroimmunology Neurology Immunology biology.protein medicine Encephalitis Humans Neurology (clinical) Antibody Receptor business Autoantibodies |
| Zdroj: | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 48(6) |
| ISSN: | 0317-1671 |
| Popis: | Neural antibodies have emerged as useful biomarkers in suspected autoimmune encephalitis. We reviewed results of neural antibody testing (anti-N-methyl D-aspartate receptor (NMDAR), leucine-rich glioma-inactivated protein (LGI1), contactin-associated protein-like 2 (CASPR2), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), γ-aminobutyric acid type B receptor (GABA(B)R), dipeptidyl-peptidase-like protein-6 (DPPX), IgLON family member 5 (IgLON5) and glutamic acid decarboxylase-65 (GAD65)) using cell-based assays (CBAs) and tissue indirect immunofluorescence (TIIF) at our centre. Our findings suggest increased clinical sensitivity of CBA compared to TIIF. However, this may come at some expense to clinical specificity, as evidenced by possible false-positive results when weak serum positivity by CBA was observed for certain antibodies (i.e. anti-NMDAR, CASPR2). In such cases, correlation with serum TIIF, as well as CSF CBA and TIIF, aids in identifying true-positive results. |
| Databáze: | OpenAIRE |
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