Anti-inflammatory effect ofSpiranthera odoratissimaA. St.-Hil. leaves involves reduction of TNF-α
| Autor: | Iziara Ferreira Florentino, Roberto do Nascimento Silva, Marcus Vinícius Mariano Nascimento, Pablinny Moreira Galdino, Adriane Ferreira de Brito, Elson Alves Costa, Frederico Argollo Vanderlinde, José Realino de Paula |
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| Rok vydání: | 2012 |
| Předmět: |
Leukocyte migration
medicine.drug_class Cell Drug Evaluation Preclinical Administration Oral Vascular permeability Inflammation Plant Science Pharmacology Carrageenan Biochemistry Anti-inflammatory Analytical Chemistry Mice chemistry.chemical_compound Leukocytes Toxicity Tests Acute medicine Animals Edema Rutaceae Peroxidase Plants Medicinal Ethanol Dose-Response Relationship Drug Plant Extracts Tumor Necrosis Factor-alpha Chemistry Anti-Inflammatory Agents Non-Steroidal Organic Chemistry Rats Plant Leaves Disease Models Animal medicine.anatomical_structure Nociception Immunology medicine.symptom Licking Brazil |
| Zdroj: | Natural Product Research. 26:2274-2279 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Spiranthera odoratissima A. St.-Hil., 'manacá', is a medicinal species used in Brazil, especially in central region, for the treatment of several diseases such as pain and inflammation. In this study, the methanol/aqueous phase of the ethanol extract of the leaves of 'manacá' (MAP), at the doses of 50, 150 and 500 mg/kg was used to evaluate the anti-inflammatory and/or antinociceptive effects and the possible anti-inflammatory mechanism. The antinociceptive and anti-inflammatory activities of MAP were assessed using formalin test, carrageenan-induced paw oedema. The myeloperoxidase activity, capillary permeability, leukocyte migration and tumour necrosis factor alpha (TNF-α) levels were evaluated in pleural exudate. The MAP reduced the licking time only in the later phase of formalin test, and showed anti-inflammatory activity by reducing the paw oedema, migration cell, myeloperoxidase activity, capillary permeability and TNF-α levels. In conclusion, we confirmed the inflammatory activity of MAP and affirm that this effect involves the reduction of TNF-α level. |
| Databáze: | OpenAIRE |
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