3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling
| Autor: | Maling Gou, Shaochen Chen, Justin Liu, Xuanyi Ma, Min Tang, Natalie Lawrence, Wei Zhu, Claire Yu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug Computer science media_common.quotation_subject Drug Evaluation Preclinical Pharmaceutical Science 02 engineering and technology Disease Computational biology Models Biological Article law.invention 03 medical and health sciences Tissue engineering law Biomimetic Materials Humans Precision Medicine media_common 3D bioprinting Tissue Engineering Drug discovery Tissue Model Bioprinting 021001 nanoscience & nanotechnology Medical research 030104 developmental biology Cardiovascular Diseases Printing Three-Dimensional 0210 nano-technology |
| Zdroj: | Advanced drug delivery reviews. 132 |
| ISSN: | 1872-8294 |
| Popis: | 3D bioprinting is emerging as a promising technology for fabricating complex tissue constructs with tailored biological components and mechanical properties. Recent advances have enabled scientists to precisely position materials and cells to build functional tissue models for in vitro drug screening and disease modeling. This review presents state-of-the-art 3D bioprinting techniques and discusses the choice of cell source and biomaterials for building functional tissue models that can be used for personalized drug screening and disease modeling. In particular, we focus on 3D-bioprinted liver models, cardiac tissues, vascularized constructs, and cancer models for their promising applications in medical research, drug discovery, toxicology, and other pre-clinical studies. |
| Databáze: | OpenAIRE |
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