Fabrication of high-quality glass microfluidic devices for bioanalytical and space flight applications
Autor: | Matin Golozar, Richard A. Mathies, Laura D. Casto, Wai K. Chu, Anna L. Butterworth, J. McCauley |
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Rok vydání: | 2020 |
Předmět: |
Computer science
media_common.quotation_subject Clinical Biochemistry Microfluidics 010501 environmental sciences 01 natural sciences law.invention Capillary electrophoresis 03 medical and health sciences Reliability (semiconductor) Glass microfabrication law Quality (business) lcsh:Science 030304 developmental biology 0105 earth and related environmental sciences media_common Scientific instrument Protocol (science) 0303 health sciences Lab-on-a-chip Quality control Method Article Astrobiology Biosignature detection Medical Laboratory Technology Systems engineering lcsh:Q Microfabrication |
Zdroj: | MethodsX, Vol 7, Iss, Pp 101043-(2020) MethodsX |
ISSN: | 2215-0161 |
DOI: | 10.1016/j.mex.2020.101043 |
Popis: | Microfabricated glass microfluidic and Capillary Electrophoresis (CE) devices have been utilized in a wide variety of applications over the past thirty years. At the Berkeley Space Sciences Laboratory, we are working to further expand this technology by developing analytical instruments to chemically explore our solar system. This effort requires improving the quality and reliability of glass microfabrication through quality control procedures at every stage of design and manufacture. This manuscript provides detailed information on microfabrication technology for the production of high-quality glass microfluidic chips in compliance with industrial standards and space flight instrumentation quality control.•The methodological protocol provided in this paper includes the scope of each step of the manufacturing process, materials and technologies recommended and the specific challenges that often confront the process developer.•Types and sources of fabrication error at every stage have been identified and their solutions have been proposed and verified.•We present robust and rigorous manufacturing and quality control procedures that will assist other researchers in achieving the highest possible quality glass microdevices using the latest apparatus in a routine and reliable fashion. Graphical abstract Image, graphical abstract |
Databáze: | OpenAIRE |
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