Half-inhibition concentrations of new cholinesterase inhibitors
| Autor: | Alexander Cegan, Karel Ventura, Karel Komers, Sarka Stepankova, Pavla Zdrazilova |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Rivastigmine
Molar concentration biology Chemistry Pharmacology Acetylcholinesterase General Biochemistry Genetics and Molecular Biology Enzyme assay Hydrolysis chemistry.chemical_compound Kinetics Butyrylcholinesterase Acetylthiocholine biology.protein medicine Animals Carbamates Cholinesterase Inhibitors Horses medicine.drug Cholinesterase |
| Zdroj: | Zeitschrift fur Naturforschung. C, Journal of biosciences. 59(3-4) |
| ISSN: | 0939-5075 |
| Popis: | The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI50 values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50 values of the commercially used drugs for the Alzheimer’s disease treatment - rivastigmine and galanthamine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|