Thrombospondin-1 Is Downregulated by Anoxia and Suppresses Tumorigenicity of Human Glioblastoma Cells

Autor: Annie-Claire Diserens, Giulia Fulci, Michael S. Pepper, Marie-France Hamou, Erwin G. Van Meir, Michele Albertoni, Mirna Tenan, Michèle El Atifi-Borel, Jean-Jacques Feige
Rok vydání: 2000
Předmět:
p53
Male
tumor
Angiogenesis
Transplantation
Heterologous
Animals
Anoxia/genetics
Anoxia/physiopathology
Base Sequence
DNA Primers/genetics
Down-Regulation
Genes
p53
Glioblastoma/blood supply
Glioblastoma/genetics
Humans
Mice
Mice
Nude
Neoplasm Transplantation
Neovascularization
Pathologic/genetics
RNA
Messenger/genetics
RNA
Messenger/metabolism
RNA
Neoplasm/genetics
RNA
Neoplasm/metabolism
Thrombospondin 1/biosynthesis
Thrombospondin 1/genetics
Tumor Cells
Cultured
Immunology
Biology
Thrombospondin 1
angiogenesis
chemistry.chemical_compound
Downregulation and upregulation
In vivo
glioma
medicine
Immunology and Allergy
Inducer
RNA
Messenger
RNA
Neoplasm
Hypoxia
DNA Primers
Neovascularization
Pathologic
GD-AIF
Hypoxia (medical)
Molecular biology
Oxygen tension
Vascular endothelial growth factor
chemistry
Cancer research
Original Article
medicine.symptom
Glioblastoma
Zdroj: The Journal of Experimental Medicine, vol. 191, no. 10, pp. 1789-1798
The Journal of Experimental Medicine
ISSN: 1540-9538
0022-1007
Popis: Angiogenesis, the sprouting of new capillaries from preexisting blood vessels, results from a disruption of the balance between stimulatory and inhibitory factors. Here, we show that anoxia reduces expression of thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, in glioblastoma cells. This suggests that reduced oxygen tension can promote angiogenesis not only by stimulating the production of inducers, such as vascular endothelial growth factor, but also by reducing the production of inhibitors. This downregulation may significantly contribute to glioblastoma development, since we show that an increase in TSP-1 expression is sufficient to strongly suppress glioblastoma cell tumorigenicity in vivo.
Databáze: OpenAIRE
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