Thrombospondin-1 Is Downregulated by Anoxia and Suppresses Tumorigenicity of Human Glioblastoma Cells
Autor: | Annie-Claire Diserens, Giulia Fulci, Michael S. Pepper, Marie-France Hamou, Erwin G. Van Meir, Michele Albertoni, Mirna Tenan, Michèle El Atifi-Borel, Jean-Jacques Feige |
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Rok vydání: | 2000 |
Předmět: |
p53
Male tumor Angiogenesis Transplantation Heterologous Animals Anoxia/genetics Anoxia/physiopathology Base Sequence DNA Primers/genetics Down-Regulation Genes p53 Glioblastoma/blood supply Glioblastoma/genetics Humans Mice Mice Nude Neoplasm Transplantation Neovascularization Pathologic/genetics RNA Messenger/genetics RNA Messenger/metabolism RNA Neoplasm/genetics RNA Neoplasm/metabolism Thrombospondin 1/biosynthesis Thrombospondin 1/genetics Tumor Cells Cultured Immunology Biology Thrombospondin 1 angiogenesis chemistry.chemical_compound Downregulation and upregulation In vivo glioma medicine Immunology and Allergy Inducer RNA Messenger RNA Neoplasm Hypoxia DNA Primers Neovascularization Pathologic GD-AIF Hypoxia (medical) Molecular biology Oxygen tension Vascular endothelial growth factor chemistry Cancer research Original Article medicine.symptom Glioblastoma |
Zdroj: | The Journal of Experimental Medicine, vol. 191, no. 10, pp. 1789-1798 The Journal of Experimental Medicine |
ISSN: | 1540-9538 0022-1007 |
Popis: | Angiogenesis, the sprouting of new capillaries from preexisting blood vessels, results from a disruption of the balance between stimulatory and inhibitory factors. Here, we show that anoxia reduces expression of thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, in glioblastoma cells. This suggests that reduced oxygen tension can promote angiogenesis not only by stimulating the production of inducers, such as vascular endothelial growth factor, but also by reducing the production of inhibitors. This downregulation may significantly contribute to glioblastoma development, since we show that an increase in TSP-1 expression is sufficient to strongly suppress glioblastoma cell tumorigenicity in vivo. |
Databáze: | OpenAIRE |
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