Expression profiling of adult acute lymphoblastic leukemia identifies a BCR-ABL1-like subgroup characterized by high non-response and relapse rates

Autor:	Peter J. M. Valk, Jan J. Cornelissen, Mathijs A. Sanders, Anita W. Rijneveld, Jasper Koenders, Judith M. Boer, Monique L. den Boer, Bronno van der Holt, Carla Exalto
Přispěvatelé:	Pediatrics, Hematology
Rok vydání:	2015
Předmět:	Adult Oncology medicine.medical_specialty Adolescent medicine.medical_treatment Fusion Proteins bcr-abl Gene Expression Antineoplastic Agents Hematopoietic stem cell transplantation Ikaros Transcription Factor Bcr abl1 Recurrence hemic and lymphatic diseases Internal medicine medicine Humans Transplantation Homologous Online Only Articles Protein Kinase Inhibitors Survival analysis Aged business.industry Gene Expression Profiling Remission Induction Hematopoietic Stem Cell Transplantation Histone-Lysine N-Methyltransferase Hematology Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma Survival Analysis Gene expression profiling Imatinib mesylate Mutation Imatinib Mesylate Adult Acute Lymphoblastic Leukemia Cancer research Myeloid-Lymphoid Leukemia Protein business
Zdroj:	EUR Research Portal Haematologica, 100. Ferrata Storti Foundation
ISSN:	1592-8721 0390-6078
DOI:	10.3324/haematol.2014.117424
Popis:	Outcome in adult precursor B-cell acute lymphoblastic leukemia (BCP-ALL) is unsatisfactory, with complete response rates of approximately 80% and event-free survival at 5 years of only 40%–50%.[1][1] This inferior survival in adult compared with pediatric patients might be explained by a higher
Databáze:	OpenAIRE
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