Subclinic arterial and left ventricular systolic impairment in autosomal dominant polycystic kidney disease with preserved renal functions
| Autor: | Murat Kose, Tevfik Ecder, Ekrem Bilal Karaayvaz, Mustafa Altinkaynak, B. Ince, Pinar Kucukdagli, Halil Yazici, Irem Sarihan, Oguz Kagan Bakkaloglu, Alpay Medetalibeyoglu, Pelin Karaca Ozer, Erol Bozbora, Duygu Uzun, Timur Selcuk Akpinar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Autosomal dominant polycystic kidney disease Pulse Wave Analysis Kidney Carotid Intima-Media Thickness chemistry.chemical_compound Predictive Value of Tests Internal medicine medicine Humans Radiology Nuclear Medicine and imaging In patient Ankle Brachial Index Pulse wave velocity Subclinical infection Creatinine business.industry Blood Pressure Monitoring Ambulatory medicine.disease Polycystic Kidney Autosomal Dominant medicine.anatomical_structure chemistry Albuminuria Arterial stiffness Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | The international journal of cardiovascular imaging. 38(2) |
| ISSN: | 1875-8312 |
| Popis: | Subclinical atherosclerosis and cardiovascular events are common even in young normotensive patients with autosomal dominant polycystic kidney disease (ADPKD). Our aim was to examine the relationship between serum fibroblast growth factor-23 (FGF-23) levels, left ventricular global longitudinal strain (LV-GLS), arterial stiffness (AS), and carotid intima-media thickness (CIMT) in patients with ADPKD with preserved kidney function. The relationship between albuminuria, AS, LV-GLS, CIMT, 24-hour ambulatory blood pressure measurement, and FGF-23 was examined in 52 normotensive and hypertensive patients with ADPKD and a matched control group of 35 subjects. AS was assesed with brachial-ankle pulse wave velocity, LV-GLS was measured with speckle-tracking echocardiography. FGF-23 was measured with enzyme-linked immunosorbent assay. The microalbumin/creatinine ratio was significantly higher in the ADPKD group than in the control group (p?0.001). Serum FGF-23 levels were similar between the study and control group. LV-GLS value tended to be impaired and CIMT to be higher in the ADPKD group compared to controls (?18.1?±?2.6 vs. -19.4?±?3.1?%, p?=?0.08; 0.75?±?0.1 vs. 0.68?±?0.1 mm, p?=?0.09, respectively). The augmentation index was significantly higher in the ADPKD group than in the control group (26.2?±?12.5 vs. 16.4?±?11.2 mmHg/mmHg, p?=?0.01). Our study supports subclinical impairment in arterial and cardiac functions in the early period of ADPKD. However, none of these factors was found to be associated with serum FGF-23 levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink