Clinical Pharmacokinetics After Repeated Intrapleural Bupivacaine Administration
| Autor: | M. Moulin, J. Tartiere, H. Bricard, J.-L. Gerard, Danièle Debruyne, M.-C. Bigot |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.drug_class Cmax Injections Pharmacokinetics medicine Humans Pharmacology (medical) Bupivacaine hydrochloride Aged Pharmacology Bupivacaine Pain Postoperative Local anesthetic business.industry Middle Aged Thoracotomy Anesthesia Toxicity Pleura Time to peak Female business Absorption rate constant medicine.drug |
| Zdroj: | Clinical Pharmacokinetics. 18:240-244 |
| ISSN: | 0312-5963 |
| DOI: | 10.2165/00003088-199018030-00005 |
| Popis: | Patients (n = 14) who underwent thoracotomy during surgery of the oesophagus for cancer received an initial intrapleural dose of 10 ml bupivacaine hydrochloride 2.5 mg/ml followed by repeated administration every 8 hours from the first to the fourth postoperative day. The mean (+/- SD) peak plasma drug concentration (Cmax) [352 +/- 120 micrograms/L], time to peak (tmax) [0.83 +/- 0.51 h], and first-order absorption rate constant (ka) [5.46 +/- 4.95 h-1] after the twelfth dose were significantly different from the Cmax (206 +/- 81 micrograms/L), tmax (1.8 +/- 1.2h), and ka (1.8 +/- 1.47 h-1) determined after the first dose. Half-life (3.5 +/- 2.2h) and mean concentration (204 +/- 105 micrograms/L) were not significantly different on the fourth day from those on the first (4.1 +/- 2.6h and 142 +/- 71 micrograms/L, respectively). No sharp peak corresponding to systemic toxicity and no accumulation could be expected with these low doses, administered at short intervals and providing good pain relief in this surgical series. |
| Databáze: | OpenAIRE |
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