Histopathologic findings in explanted heart tissue from patients with end-stage idiopathic dilated cardiomyopathy

Autor: Jochem M. D. Galama, Aggie H.M.M. Balk, Willem J. G. Melchers, Dirk J. Ruiter, Nicolaas de Jonge, Nicole De Leeuw
Přispěvatelé: Cardiology
Rok vydání: 2001
Předmět:
Nephrology
Adult
Cardiomyopathy
Dilated
Immunologische ontstekingsprocessen in de nier
medicine.medical_specialty
Pathology
Heart disease
T-Lymphocytes
Pathogenese
epidemiologie en behandeling van microbiële infecties
CD8-Positive T-Lymphocytes
In Vitro Techniques
Pathogenesis
epidemiology
and treatment of microbial infections
Pathogenesis
Fibrosis
Inflammatory reactions in the kidneys
Internal medicine
Idiopathic dilated cardiomyopathy
medicine
Humans
skin and connective tissue diseases
neoplasms
Chromosomal aberrations and cancer
Cell Nucleus
Inflammation
Transplantation
Chromosomale aberraties en kanker
business.industry
Myocardium
Patient Selection
Endocardial fibroelastosis
medicine.disease
Immunohistochemistry
body regions
Cardiology
Heart Transplantation
Histopathology
Female
business
Zdroj: Transplant International, 14, 299-306. Wiley-Blackwell Publishing Ltd
Transplant International, 14, 299--306
Transplant International, 14, 5, pp. 299--306
ISSN: 1432-2277
0934-0874
DOI: 10.1007/s001470100339
Popis: Item does not contain fulltext Explanted hearts were examined to determine whether specific histopathologic features are present in the myocardium of patients with end-stage idiopathic dilated cardiomyopathy (IDC). Extensive histopathologic examination by light microscopy, electron microscopy and immunohistochemistry revealed marked fibrosis in the hearts of 21 of 37 IDC patients and in 26 of 35 patients with heart diseases of known causes. Reactive (interstitial and perivascular) fibrosis predominated in the IDC hearts, whereas both reparative (replacement) fibrosis and reactive fibrosis were found in the comparison group. Endocardial fibroelastosis was found in nine patients with IDC and in 14 patients from the comparison group. Distinct patterns of fibrosis were the sole significant histopathologic difference between myocardial samples from patients with IDC and from those with heart diseases of known causes. The diffuse presence of reactive fibrosis in IDC patients suggests a more generalised dysfunction that affects the composition of the myocardial extracellular matrix.
Databáze: OpenAIRE
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