Creatinine clearance, pulse wave velocity, carotid compliance and essential hypertension
| Autor: | Bruno Pannier, Annie Rudnichi, Jean-Jacques Mourad, Michel E. Safar, Jacques Blacher, Gérard M. London, Athanase Benetos |
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| Rok vydání: | 2001 |
| Předmět: |
cardiovascular risk factors
Adult Male medicine.medical_specialty Hemodynamics Renal function Kidney Essential hypertension chemistry.chemical_compound Risk Factors Internal medicine medicine Humans Pulse wave velocity Aorta Aged Aged 80 and over Creatinine end-stage renal disease hemodialysis business.industry blood pressure Middle Aged medicine.disease arterial stiffness Carotid Arteries Endocrinology Blood pressure chemistry Cardiovascular Diseases Nephrology Pulsatile Flow Hypertension Radial Artery Arterial stiffness Cardiology Kidney Failure Chronic Female business viscoelastic properties of arteries Blood Flow Velocity Kidney disease |
| Zdroj: | Kidney International. 59:1834-1841 |
| ISSN: | 0085-2538 |
| Popis: | Creatinine clearance, pulse wave velocity, carotid compliance and essential hypertension. Background The vascular hallmark of subjects with end-stage renal disease is increased arterial stiffness independent of blood pressure, wall stress, and cardiovascular risk factors such as hypertension, plasma glucose and cholesterol, obesity, and tobacco consumption. Whether arterial stiffness and kidney function are statistically associated in subjects with plasma creatinine ≤130 μmol/L has not yet been determined. Material In 1290 subjects with normal or elevated blood pressure values and plasma creatinine ≤130 μmol/L, subjects were divided into three tertiles according to the calculated creatinine clearance. Blood pressure, aortic pulse wave velocity (PWV), and standard cardiovascular risk factors were determined in parallel. In 112 of the hypertensive subjects, common carotid and radial artery structure and function (high-resolution echo-Doppler techniques) also were measured. Results From the 1290 subjects, only the low-tertile group presented a significant negative association between PWV and creatinine clearance independently of blood pressure and standard risk factors. This association was stronger in subjects ≤55 years of age. In the 112 hypertensive subjects, carotid compliance was positively correlated to creatinine clearance even after an adjustment for age, gender, and blood pressure. At less than 55 years of age, creatinine clearance represented 20% of the variance of carotid compliance. Such findings were not observed for radial artery compliance. Conclusion Increased stiffness of central arteries is statistically associated with reduced creatinine clearance in subjects with mild-to-moderate renal insufficiency, indicating that kidney alterations may interact not only with small but also large arteries, and this is independent of age, blood pressure, and standard risk factors. |
| Databáze: | OpenAIRE |
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