Intrinsic neuronal properties represent song and error in zebra finch vocal learning
| Autor: | Daniel Margoliash, Arij Daou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine animal structures High Vocal Center Science Models Neurological Population Action Potentials General Physics and Astronomy Biology Neural circuits Article General Biochemistry Genetics and Molecular Biology Learning and memory 03 medical and health sciences 0302 clinical medicine Feedback Sensory Motor control Cellular neuroscience Neuroplasticity Biological neural network Animals Learning lcsh:Science education Zebra finch Neurons Auditory feedback education.field_of_study Neuronal Plasticity Multidisciplinary General Chemistry 030104 developmental biology nervous system Forebrain Basal ganglia behavior and behavior mechanisms lcsh:Q Vocal learning Finches Nerve Net Vocalization Animal Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Neurons regulate their intrinsic physiological properties, which could influence network properties and contribute to behavioral plasticity. Recording from adult zebra finch brain slices we show that within each bird basal ganglia Area X–projecting (HVCX) neurons share similar spike waveform morphology and timing of spike trains, with modeling indicating similar magnitudes of five principal ion currents. These properties vary among birds in lawful relation to acoustic similarity of the birds’ songs, with adult sibling pairs (same songs) sharing similar waveforms and spiking characteristics. The properties are maintained dynamically: HVCX within juveniles learning to sing show variable properties, whereas the uniformity rapidly degrades within hours in adults singing while exposed to abnormal (delayed) auditory feedback. Thus, within individual birds the population of current magnitudes covary over the arc of development, while rapidly responding to changes in feedback (in adults). This identifies network interactions with intrinsic properties that affect information storage and processing of learned vocalizations. The regulation of cellular neuronal properties distinct from synaptic plasticity has been proposed as a mechanism of functional network organization. Here, the authors show that the magnitude of five ion currents in basal ganglia projection song system forebrain neurons covary across life, rapidly and dynamically relating to learned features of individual zebra finches’ songs. |
| Databáze: | OpenAIRE |
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