Digoxin in hyperthyroidism
| Autor: | C. D. Klaassen, C. R. Hartman, David H. Huffman |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Ventricular rate Digoxin endocrine system diseases Hyperthyroidism Excretion Iodine Radioisotopes Biliary excretion Internal medicine Atrial Fibrillation polycyclic compounds medicine Chronic atrial fibrillation Animals Bile Humans Pharmacology (medical) cardiovascular diseases Pharmacology business.industry digestive oral and skin physiology Therapeutic effect Atrial fibrillation Metabolism Middle Aged medicine.disease Rats carbohydrates (lipids) Endocrinology Female business medicine.drug |
| Zdroj: | Clinical pharmacology and therapeutics. 22(5 Pt 1) |
| ISSN: | 0009-9236 |
| Popis: | A patient with chronic atrial fibrillation developed hyperthyroidism. Increasing doses of digoxin were required to maintain satisfactor ventricular rate control. The systemic availability of oral digoxin was decreased in this patient. The metabolism of digoxin was studied in the hyperthyroid rats. The plasma digoxin concentrations were significantly decreased in the hyperthyroid rats. A threefold increase in digoxin excretion in the bile of the hyperthyroid rats was associated with these changes in plasma digoxin concentrations. Conversely, hypothyroid rats excreted less digoxin in the bile when compared with control and hyperthyroid rats. Thus, changes in digoxin absorption and its biliary excretion result, in part, in a decreased therapeutic effect of digoxin based on dose in hyperthyroidism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|