Structures of New Friedelane-Type Triterpenes and Eudesmane-Type Sesquiterpene and Aldose Reductase Inhibitors from Salacia chinensis
| Autor: | Akinobu Kishi, Yutana Pongpiriyadacha, Hisashi Matsuda, Toshio Morikawa, Masayuki Yoshikawa |
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| Rok vydání: | 2003 |
| Předmět: |
Salacia chinensis
Stereochemistry Pharmaceutical Science Sesquiterpene Analytical Chemistry Terpene chemistry.chemical_compound Triterpene Aldehyde Reductase Drug Discovery Animals Sesquiterpenes Eudesmane Enzyme Inhibitors Mangiferin Pharmacology chemistry.chemical_classification Aldose reductase Plants Medicinal Molecular Structure Chemistry Hydrolysis Organic Chemistry Stereoisomerism Thailand Triterpenes Terpenoid Rats Complementary and alternative medicine Molecular Medicine |
| Zdroj: | Journal of Natural Products. 66:1191-1196 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np0301543 |
| Popis: | Three new friedelane-type triterpenes named salasones A (1), B (2), and C (3), a new norfriedelane-type triterpene, salaquinone A (4), and a new acylated eudesmane-type sesquiterpene, salasol A (5), were isolated from the 80% aqueous methanolic extract of the stems of Salacia chinensis collected in Thailand. Their stereostructures were elucidated on the basis of chemical and physicochemical evidence. In addition, six constituents, 3beta,22beta-dihydroxyolean-12-en-29-oic acid, tingenone, tingenine B, regeol A, triptocalline A, and mangiferin, were found to show an inhibitory effect on rat lens aldose reductase. |
| Databáze: | OpenAIRE |
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