Clinicopathological study of nondiabetic renal disease in type 2 diabetic patients: A single center experience from India
| Autor: | Kamlesh S Suthar, Kamal V Kanodia, Rashmi D Patel, Himanshu V Patel, Lovelesh A Nigam, Aruna V Vanikar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Nephrotic Syndrome Glomerulonephritis Membranoproliferative Biopsy 030232 urology & nephrology India lcsh:Medicine 030209 endocrinology & metabolism Kidney Gastroenterology Glomerulonephritis Membranous Nephropathy Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Membranous nephropathy Risk Factors Diabetes mellitus Internal medicine Benign nephrosclerosis medicine Prevalence Humans Diabetic Nephropathies Aged Retrospective Studies Proteinuria Diabetic Retinopathy business.industry Incidence lcsh:R Complement C4 Glomerulonephritis IGA General Medicine Complement C3 Middle Aged medicine.disease Diabetes Mellitus Type 2 Nephritis Interstitial Female Kidney Diseases medicine.symptom business Nephrotic syndrome Biomarkers Kidney disease |
| Zdroj: | Saudi Journal of Kidney Diseases and Transplantation, Vol 28, Iss 6, Pp 1330-1337 (2017) |
| ISSN: | 1319-2442 |
| Popis: | Diabetic nephropathy (DN) is a major complication of diabetes mellitus (DM), leading to chronic kidney disease/end-stage renal disease. Wide spectrum of nondiabetic renal diseases (NDRD) is reported in type-2 diabetes (type-2 DM). We carried out this single-center study to find clinical, laboratory, and histological features of NDRD in type-2 DM patients and to assess the prevalence of NDRD in India. A single-center retrospective study which included analysis of renal biopsies from patients with type-2 DM, performed between January 2008 and September 2016. Biopsy findings were categorized into three groups, Group-I (isolated NDRD); Group-II (NDRD superimposed on underlying DN); and Group-III (isolated DN). Out of 152 diabetic patients (111 males and 41 females), 35 (23.03%) patients were of Group-I (isolated NDRD), 35 (23.03%) of Group-II (NDRD superimposed on underlying DN), and 82 (53.95%) of Group-III (isolated DN). The mean age (in years) was 55.08 ± 10.71, 55.65 ± 8.71, and 54.45 ± 9.01 respectively in Group-I, II, and III. Nephrotic syndrome (NS) was the most common clinical presentation in all groups. Duration of DM was significantly shorter in Group-I than in Group-II. Diabetic retinopathy was absent in Group-I. Proteinuria was more in Group-III than Group-I. Low serum C3 and/or C4 levels was observed in five (14.29%) cases of Group-I and Group-II each and two (2.43%) cases of Group-III. Nearly, 70 (46.05%) patients were found to have NDRD either in isolated form or as combined lesions. The most common histological types of NDRD were acute tubulointerstitial nephritis (38.57%) followed by benign nephrosclerosis (15.72%), membranous nephropathy (10%), IgA nephropathy (7.14%), and membranoproliferative glomerulonephritis (7.14%). The incidence of NDRD (with/without DN) in type-2 DM is very high. Shorter duration of diabetes, hematuria, absence of retinopathy, low serum complement levels, and nephrotic range proteinuria are predictors of NDRD. |
| Databáze: | OpenAIRE |
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