Addition of cranberry to proton pump inhibitor-based triple therapy for Helicobacter pylori eradication
| Autor: | Jamshid Vafaeimanesh, Majid Rajabikashani, Mona Firoozabadi, Anahita Ahmadi, Mohammadreza Seyyedmajidi, Shahin Hajiebrahimi, Seyedali Seyedmajidi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class 030106 microbiology Antibiotics Lansoprazole lcsh:RS1-441 Proton-pump inhibitor Pharmacy Gastroenterology lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Cranberry eradication therapy Helicobacter pylori Internal medicine Clarithromycin medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Breath test medicine.diagnostic_test biology business.industry Amoxicillin biology.organism_classification Surgery Regimen 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Journal of Research in Pharmacy Practice, Vol 5, Iss 4, Pp 248-251 (2016) |
| ISSN: | 2279-042X |
| Popis: | Objective: Proton pump inhibitor-based triple therapy with two antibiotics for Helicobacter pylori eradication is widely accepted, but this combination fails in a considerable number of cases. Some studies have shown that cranberry inhibits the adhesion of a wide range of microbial pathogens, including H. pylori. The aim of this study was to assess the effect of cranberry on H. pylori eradication with a standard therapy including lansoprazole, clarithromycin, and amoxicillin (LCA) in patients with peptic ulcer disease (PUD). Methods: In this study, H. pylori-positive patients with PUD were randomized into two groups: Group A: A 14-day LCA triple therapy with 30 mg lansoprazole bid, 1000 mg amoxicillin bid, and 500 mg clarithromycin bid; Group B: A 14-day 500 mg cranberry capsules bid plus LCA triple therapy. A 13C-urea breath test was performed for eradication assessment 6 weeks after the completion of the treatment. Findings: Two hundred patients (53.5% males, between 23 and 77 years, mean age ± standard deviation: 50.29 ± 17.79 years) continued treatment protocols and underwent 13C-urea breath testing. H. pylori eradication was achieved in 74% in Group A (LCA without cranberry) and 89% in Group B (LCA with cranberry) (P = 0.042). Conclusion: The addition of cranberry to LCA triple therapy for H. pylori has a higher rate of eradication than the standard regimen alone (up to 89% and significant). |
| Databáze: | OpenAIRE |
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