SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease
| Autor: | Mar Hernández-Guillamon, Ping Sun, Montse Solé, Mercedes Unzeta |
|---|---|
| Přispěvatelé: | Institut Català de la Salut, [Unzeta M] Departament de Bioquímica i Biologia Molecular, Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Hernàndez-Guillamon M, Solé M] Laboratori de Recerca Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sun P] Department of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA, Vall d'Hebron Barcelona Hospital Campus |
| Rok vydání: | 2021 |
| Předmět: |
Amino oxidases - Metabolisme
0301 basic medicine blood–brain barrier dysfunction Malalties cerebrovasculars - Tractament enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares [ENFERMEDADES] Review Vascular damage Disease Pharmacology medicine.disease_cause lcsh:Chemistry Mice 0302 clinical medicine Leukocytes oxidative stress Amines neurovascular unit lcsh:QH301-705.5 Stroke Otros calificadores::/terapia [Otros calificadores] Blood-brain barrier dysfunction Spectroscopy Otros calificadores::Otros calificadores::/metabolismo [Otros calificadores] Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders [DISEASES] Other subheadings::Other subheadings::/metabolism [Other subheadings] General Medicine Alzheimer's disease stroke Pathophysiology Computer Science Applications SSAO/VAP-1 Disease Progression Neurovascular unit Amine Oxidase (Copper-Containing) medicine.symptom Alzheimer’s disease Amine oxidase Inflammation Brain damage Catalysis Inorganic Chemistry 03 medical and health sciences Alzheimer Disease vascular damage Cell Adhesion medicine Animals Humans Physical and Theoretical Chemistry Molecular Biology Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-NH2 Group Donors::Amine Oxidase (Copper-Containing) [CHEMICALS AND DRUGS] business.industry Organic Chemistry Endothelial Cells enzimas y coenzimas::enzimas::oxidorreductasas::oxidorreductasas que actúan sobre donantes de grupos CH-NH2::amina oxidasa (con cobre) [COMPUESTOS QUÍMICOS Y DROGAS] Other subheadings::/therapy [Other subheadings] Human physiology medicine.disease Rats Cerebral Amyloid Angiopathy Cerebrovascular Disorders Glucose 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Oxidative stress business Cell Adhesion Molecules 030217 neurology & neurosurgery |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona International Journal of Molecular Sciences, Vol 22, Iss 3365, p 3365 (2021) International Journal of Molecular Sciences Scientia |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22073365 |
| Popis: | Alzheimer’s disease; Inflammation; Vascular damage Malaltia d'Alzheimer; Inflamació; Lesions vasculars Enfermedad de Alzheimer; Inflamación; Lesión vascular The semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1) or primary amine oxidase (PrAO), is a deaminating enzyme highly expressed in vessels that generates harmful products as a result of its enzymatic activity. As a multifunctional enzyme, it is also involved in inflammation through its ability to bind and promote the transmigration of circulating leukocytes into inflamed tissues. Inflammation is present in different systemic and cerebral diseases, including stroke and Alzheimer’s disease (AD). These pathologies show important affectations on cerebral vessels, together with increased SSAO levels. This review summarizes the main roles of SSAO/VAP-1 in human physiology and pathophysiology and discusses the mechanisms by which it can affect the onset and progression of both stroke and AD. As there is an evident interrelationship between stroke and AD, basically through the vascular system dysfunction, the possibility that SSAO/VAP-1 could be involved in the transition between these two pathologies is suggested. Hence, its inhibition is proposed to be an interesting therapeutical approach to the brain damage induced in these both cerebral pathologies. This research received no external funding. The Neurovascular Research Laboratory is part of the INVICTUS+ network, ISCIII, Spain (RD16/0019/0021). |
| Databáze: | OpenAIRE |
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