Maternal hypothyroxinaemia in early pregnancy and school performance in 5-year-old offspring
| Autor: | Peter M. van de Ven, A S Paul van Trotsenburg, Joost Rotteveel, Manon van Eijsden, Martijn J J Finken, Anna M E Noten, Tanja G. M. Vrijkotte, E.M. Loomans |
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| Přispěvatelé: | Epidemiology and Data Science, Pediatric surgery, ICaR - Circulation and metabolism, APH - Amsterdam Public Health, ARD - Amsterdam Reproduction and Development, Public and occupational health, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Paediatric Endocrinology |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Percentile Offspring Endocrinology Diabetes and Metabolism Population Endocrinology Child Development Hypothyroidism Pregnancy Internal medicine medicine Humans Longitudinal Studies Registries education Netherlands education.field_of_study Intelligence quotient Obstetrics business.industry Gestational age General Medicine Odds ratio medicine.disease Pregnancy Complications Thyroxine Child Preschool Prenatal Exposure Delayed Effects Female Educational Measurement Thyroid function business |
| Zdroj: | Noten, A M E, Loomans, E M, Vrijkotte, T G M, van de Ven, P M, van Trotsenburg, A S P, Rotteveel, J, Eijsden, M & Finken, M J J 2015, ' Maternal hypothyroxinaemia in early pregnancy and school performance in 5-year-old offspring ', European Journal of Endocrinology, vol. 173, no. 5, pp. 563-571 . https://doi.org/10.1530/EJE-15-0397 European Journal of Endocrinology, 173(5), 563-571. BioScientifica Ltd. European journal of endocrinology / European Federation of Endocrine Societies, 173(5), 563-571. BioScientifica Ltd. |
| ISSN: | 0804-4643 |
| DOI: | 10.1530/EJE-15-0397 |
| Popis: | ObjectiveOvert hypothyroidism in pregnant women is associated with a lower intelligence quotient in their children. More recently, subtle decreases in maternal thyroid function have also been associated with neurodevelopmental impairment in offspring. We tested the effect of hypothyroxinaemia during early pregnancy on school performance.DesignThis was a longitudinal study that included the data of 1196 mother-child pairs from the Amsterdam Born Children and Their Development study.MethodsMaternal serum free thyroxine (T4) and TSH were obtained at a median gestational age of 12.9 (interquartile range: 11.9–14.3) weeks. School performance was assessed at age 5 years and based on scores obtained in arithmetic and language tests from the national monitoring and evaluation system. Poor school performance was defined as a test result ResultsMaternal hypothyroxinaemia (i.e., a maternal free T4 in the lowest 10% of distribution) was associated with a 1.61 (95% CI: 1.05–2.47) -fold increased odds of subnormal arithmetic performance after adjustment for confounders (P=0.03). However, the odds ratio dropped to 1.48 (95% CI: 0.94–2.32) after inverse-probability weighting (P=0.09). No such relations were found with TSH.ConclusionsMaternal hypothyroxinaemia at the end of the first trimester was associated with reduced performance in an arithmetic test, but not in a language test, in 5-year-old offspring. However, our results should be interpreted carefully because of possible non-response bias. |
| Databáze: | OpenAIRE |
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