Effects of Allopurinol on Ischemia and Reperfusion in Rabbit Livers
| Autor: | M O, Taha, M J, Simões, E C, Noguerol, F P, Mendonça, H M A, Pascoalick, R A M, Alves, M E M, Vivian, F P, Morales, A C A, Campos, K G, Magalhães, P S, Venerando, I L S, Tersariol, H P, Monteiro, I S, Oliveira-Júnior, I, Oliveira, A, Jurkiewicz, A, Caricati-Neto |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Xanthine Oxidase medicine.medical_specialty Allopurinol Ischemia chemistry.chemical_compound Internal medicine medicine Animals Aspartate Aminotransferases Enzyme Inhibitors Xanthine oxidase Transplantation Lagomorpha L-Lactate Dehydrogenase biology Superoxide business.industry Liver Diseases Alanine Transaminase medicine.disease biology.organism_classification Endocrinology chemistry Biochemistry Enzyme inhibitor Apoptosis Reperfusion Injury biology.protein Surgery Rabbits business medicine.drug |
| Zdroj: | Transplantation Proceedings. 41:820-823 |
| ISSN: | 0041-1345 |
| Popis: | In this work, we evaluated the effects of allopurinol (ALO), an inhibitor of xanthine oxidase (XO), on hepatic lesions caused by ischemia/reperfusion (I/R) in the rabbit liver. Rabbits were pretreated with ALO (10 mg/kg IV) or saline solution 0.9% before the hepatic I/R procedure. The effects of ALO on hepatic injury were evaluated before and after I/R. A standard, warm hepatic I/R procedure caused profound acute liver injury, as indicated by elevated serum aspartate aminotransferase, alanine aminotransferase, and lactic dehydrogenase levels, as well as a high apoptotic cell count. All of these changes were reversed by the administration of ALO before the hepatic I/R procedure. In conclusion, ALO exerted protective effects on hepatic I/R lesions. This protective effect of ALO was probably associated with blocking the generation of superoxide anions during the hepatic I/R procedure by inhibiting XO activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect