Longitudinal white matter microstructural change in Parkinson’s disease
| Autor: | Catherine L. Gallagher, Stephanie Krislov, Vincent Pozorski, Jitka Sojkova, Barbara B. Bendlin, Andrew P. Merluzzi, Andrew L. Alexander, Frances Theisen, Nagesh Adluru, Amy Barzgari, Sterling C. Johnson, Jennifer M. Oh, Ozioma C. Okonkwo |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Postmortem studies Pathology medicine.medical_specialty Aging Parkinson's disease Severity of Illness Index Article White matter 03 medical and health sciences 0302 clinical medicine Fractional anisotropy Medicine Humans Radiology Nuclear Medicine and imaging Longitudinal Studies Aged Neocortex Radiological and Ultrasound Technology Lewy body business.industry Parkinson Disease Limbic lobe Middle Aged medicine.disease White Matter 030104 developmental biology medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Neurology Disease Progression Female Neurology (clinical) Brainstem Anatomy business 030217 neurology & neurosurgery |
| Popis: | Post-mortem studies of Parkinson’s disease (PD) suggest that Lewy body pathology accumulates in a predictable topographical sequence, beginning in the olfactory bulb, followed by caudal brainstem, substantia nigra, limbic cortex, and neocortex. Diffusion weighted imaging (DWI) is sensitive, if not specific, to early disease-related white matter (WM) change in a variety of traumatic and degenerative brain diseases. Although numerous cross-sectional studies have reported DWI differences in cerebral WM in PD, only a few longitudinal studies have investigated whether DWI change exceeds that of normal aging or coincides with regional Lewy body accumulation. The present study mapped regional differences in the rate of DWI-based microstructural change between 29 PD patients and 43 age-matched controls over 18 months. Iterative within- and between-subject tensor-based registration was completed on motion- and eddy current-corrected DWI images, then baseline versus follow-up difference maps of fractional anisotropy, mean, radial, and axial diffusivity were analyzed in the Biological Parametric Mapping toolbox for MATLAB. This analysis showed that PD patients had a greater decline in WM integrity in the rostral brainstem, caudal subcortical WM, and cerebellar peduncles, compared with controls. In addition, patients with unilateral clinical signs at baseline experienced a greater rate of WM change over the 18-month study than patients with bilateral signs. These findings suggest that rate of WM microstructural change in PD exceeds that of normal aging and is maximal during early-stage disease. In addition, the neuroanatomic locations (rostral brainstem and subcortical WM) of accelerated WM change fit with current theories of topographic disease progression. |
| Databáze: | OpenAIRE |
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