Pharmacokinetics of four fluoroquinolones in an animal model of infected lung
| Autor: | Jean-Jacques Pocidalo, E Azoulay-Dupuis, E Vallée, E. Bergogne-Berezin |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Lung Diseases
Microbiology (medical) Ofloxacin Mice Inbred Strains Quinolones Pharmacology medicine.disease_cause Pneumococcal Infections Mice Subcutaneous injection Anti-Infective Agents Pharmacokinetics Ciprofloxacin Streptococcus pneumoniae medicine Animals heterocyclic compounds Pharmacology (medical) Antibacterial agent business.industry Temafloxacin biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease respiratory tract diseases Disease Models Animal Pneumonia Infectious Diseases Sparfloxacin Immunology business Fluoroquinolones medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 28:39-44 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/28.suppl_c.39 |
| Popis: | We studied the pharmacokinetic parameters of four fluoroquinolones--ofloxacin, ciprofloxacin, temafloxacin and sparfloxacin--in a mouse model of Streptococcus pneumoniae-infected lung. After a single subcutaneous injection, bioactivities were determined concomitantly in non-infected and infected animals, at a time at which pneumonia was well developed. Fluoroquinolones exhibited generally good activity at the site of infection. Infection did not affect the tissue distribution of either drug. However, the differences observed in non-infected controls (greater AUCs and longer half-lives of temafloxacin and sparfloxacin in lung and serum) were accentuated in infected mice, with probable trapping of temafloxacin and sparfloxacin at the site of infection and more persistent activity in the lung. These data suggest that the anti-pneumococcal activity of temafloxacin, and to a lesser extent sparfloxacin, were greatly favoured by their pharmacokinetic behaviour in the infected lung. |
| Databáze: | OpenAIRE |
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