Manipulation of the mouse genome: a multiple impact resource for drug discovery and development
| Autor: | Sohaila Rastan, Haydn M. Prosser |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Genome
Scope (project management) business.industry Drug discovery Process (engineering) Gene Expression Profiling Mice Transgenic Bioengineering Genomics Biology Data science Biotechnology Mice Gene Expression Regulation Drug development Drug Design Animals Humans Pharmaceutical sciences Genetic Engineering business Pharmaceutical industry |
| Zdroj: | Trends in Biotechnology. 21:224-232 |
| ISSN: | 0167-7799 |
| DOI: | 10.1016/s0167-7799(03)00087-8 |
| Popis: | Few would deny that the pharmaceutical industry's investment in genomics throughout the 1990s has yet to deliver in terms of drugs on the market. The reasons are complex and beyond the scope of this review. The unique ability to manipulate the mouse genome, however, has already had a positive impact on all stages of the drug discovery process and, increasingly, on the drug development process too. We give an overview of some recent applications of so-called 'transgenic' mouse technology in pharmaceutical research and development. We show how genetic manipulation in the mouse can be employed at multiple points in the drug discovery and development process, providing new solutions to old problems. |
| Databáze: | OpenAIRE |
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