Karyotypic findings as an independent prognostic marker in chronic myeloid leukaemia blast crisis
| Autor: | Harpreet Chopra, P. R. Kadam, G. Nanjangud, Ashok Kumar, Tapan K. Saikia, Ramakrishnan Gopal, Suresh H. Advani, Chandrika N. Nair, Avinash N. Bhisey |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Blast Crisis Myeloid Blastic Phase Gastroenterology Translocation Genetic hemic and lymphatic diseases Internal medicine Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Univariate analysis biology Calla Incidence (epidemiology) Cytogenetics Hematology biology.organism_classification medicine.disease Prognosis medicine.anatomical_structure Basophilia Oncology Karyotyping Female |
| Zdroj: | Leukemia research. 18(5) |
| ISSN: | 0145-2126 |
| Popis: | Fifty-three patients with Ph positive chronic myeloid leukaemia in blastic phase were studied. Additional abnormalities were found in 29 (55%) patients and were more common in myeloid (64%) than lymphoid (45%) blast crisis. The most frequent were +Ph (32%), +8 (28%), +19 (19%), +20 (9%) and +21 (9%). i(17q) (9%) was associated with thrombocytopenia ( 5 5 ) and basophilia ( 2 5 ). The incidence of additional abnormalities was higher in patients treated with busulphan (70%) than hydroxyurea (44%). No significant differences were noted in the mean values of the clinical and haematological findings recorded at blast crisis between patients with only Ph positive (PP) cells and those with additional abnormalities (AP + AA). Univariate analysis identified karyotypic findings as an independent prognostic marker indicating its significance in assessing the response to therapy and survival after the onset of transformation. |
| Databáze: | OpenAIRE |
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